RecruitingNot ApplicableNCT06671535

Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis

Sponsor

Saint Petersburg State University, Russia

Enrollment

62 participants

Start Date

Jan 27, 2025

Study Type

INTERVENTIONAL

Conditions

Hemodialysis CKD (Chronic Kidney Disease) Stage 5D Pruritis

Summary

This randomized controlled trial aims to evaluate the effect of polymethylmethacrylate dialysis membranes use on the intensity of pruritus in patients with CKD stage 5D receiving maintenance hemodialysis. The main question it aims to answer is: Does the use of polymethylmethacrylate (PMMA) membranes reduce the intensity of pruritus in dialysis patients? Researchers will compare PMMA membranes to standard polysulfone-based membranes to see if PMMA works to reduce moderate-to-severe pruritis and pruritis-related quality of life. Participants will: * receive maintenance hemodialysis with PMMA or polysulfone membranes for 2 months; * fill in questionnaires about intensity of pruritis and its impact on daily life.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether switching to a specific type of dialysis membrane (polymethylmethacrylate, or PMMA) can reduce severe itching in patients on long-term kidney dialysis. Persistent itching is a very common and distressing problem for dialysis patients. **You may be eligible if...** - You have end-stage kidney disease (stage 5D) and have been on maintenance dialysis for at least 3 months - You experience moderate to severe itching (score of 4 or higher on the itch scale) - You receive dialysis three times per week, each session lasting at least 4 hours - Your dialysis dose meets the adequacy requirements **You may NOT be eligible if...** - Your itching is likely caused by something other than kidney disease (e.g., a skin condition, bile duct disease, or severe overactive parathyroid glands) - You are receiving a type of dialysis called haemodiafiltration - Your doctor does not think you can comply with the study protocol Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICEPolymethylmethacrylate membrane

A polymethylmethacrylate hollow fiber membrane (PMMA membrane) has unique properties including the uniform structure and the adsorption property.

DEVICEpolysulfone membranes

Dialyzers containing polysulfone membranes are widely used for modern dialysis therapies as they allow efficient removal of a broad spectrum of uremic toxins.