RecruitingNCT06672497

Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity of Skeletal Muscle Mitochondria in Breast Cancer and All Gynecological Cancer Patients

Sponsor

University of South Carolina

Enrollment

30 participants

Start Date

Sep 7, 2021

Study Type

OBSERVATIONAL

Conditions

Breast Cancer Gynecologic Cancers Mitochondrial Function

Summary

Participants recruited for this study will be breast cancer or gynecological cancer patients who agree to participate in an exercise study examining the effects of chemotherapy on muscle mitochondrial oxidative capacity, a measure of skeletal muscle health. Participants will ride a stationary bicycle and the quadriceps muscle will be non-invasively evaluated.

Eligibility

Sex: FEMALEMin Age: 20 Years

Inclusion Criteria5

Patients diagnosed with breast cancer or gynecological cancer without distance metastasis
Able to perform exercise on a stationary cycle ergometer at moderate intensities for a maximum of 15 minutes
Hemoglobin values greater than 10 at baseline
ALT and AST values less than 2.5X the upper limit of normal by institutional standards
Godin-Shepard Leisure time Physical Activity Questionnaire (GLTEQ) score of 14 or greater will be included. A score of less than 14 is considered insufficiency active/sedentary

Exclusion Criteria11

Metastatic breast or gynecological cancer
Clinically advanced cardiovascular disease
Clinically advanced pulmonary disease
Disease requiring continuous oxygen supplementation
Greater than 2 centimeters or more of subcutaneous adipose tissue on the anterior thigh
Inability to walk or stand
Movement disorders
Spinal cord injuries
Autoimmune disorders
Pregnant or breastfeeding
Mini-Mental State Examination (MMSE) \<24