RecruitingPhase 4NCT06676280

ASpirin Use and stAtin Strategy for Primary Prevention in Severe Coronary Calcium Score on Computed Tomography

an Investigator-initiated, Multicenter, Open-label, 2-by-2 Factorial, and Randomized Trial to Evaluate the Role of Aspirin and High-intensity Statin Therapy, Respectively, in Individuals With Severe Coronary Calcification (Coronary Calcium Score ≥300) to Prevent Atherosclerotic Cardiovascular Disease (ASCVD) Events With Severe Coronary Calcification (CAC ≥300)

Sponsor

Jung-min Ahn

Enrollment

5,000 participants

Start Date

Jul 24, 2025

Study Type

INTERVENTIONAL

Conditions

Cardiovascular Diseases

Summary

The primary objective of the ASA-3C trial is to evaluate the role of aspirin and high-intensity statin therapy, respectively, in individuals with severe coronary calcification (coronary calcium score ≥300) to prevent atherosclerotic cardiovascular disease (ASCVD) events with severe coronary calcification (CAC ≥300).

Eligibility

Min Age: 40 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This trial studies whether taking aspirin and/or a statin medication reduces the risk of a first heart attack or stroke in people with high coronary artery calcium scores — a sign of significant plaque buildup in the arteries. **You may be eligible if...** - You are between 40 and 70 years old - Your coronary artery calcium score is 300 or higher on a CT scan - You have one or more heart disease risk factors (high cholesterol, diabetes, high blood pressure, family history, or smoking) **You may NOT be eligible if...** - You already have symptoms of coronary artery disease or heart failure - You have had a prior heart attack, stroke, TIA, bypass surgery, or other major cardiovascular event - You already have evidence of reduced blood flow to the heart on imaging - You take aspirin or statins for an existing cardiovascular condition Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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