RecruitingNCT06678100

Swallowing Impairments in Adults With and Without Alzheimer's Disease

Prevalence and Care Partner Burden of Individuals With Alzheimer's Disease


Sponsor

Vanderbilt University Medical Center

Enrollment

240 participants

Start Date

Apr 21, 2025

Study Type

OBSERVATIONAL

Conditions

Summary

This research study is investigating whether people with Alzheimer's disease (AD) experience more changes to swallowing than their healthy age-matched peers. The prevalence of swallowing impairments in moderate-severe AD is high (85-93%), yet little is known about how swallow function evolves throughout the disease course in people with AD. The overall objective of this study is to evaluate swallowing function in adults with and without Alzheimer's disease. The investigator will also be involving the primary caregivers of individuals with Alzheimer's that are enrolled in the study to better understand the impact of swallowing impairments on the primary caregivers of those with Alzheimer's Disease. Healthy adults and individuals with Alzheimer's disease will: * undergo tests of cough and swallow function * undergo tests of grip and tongue strength * complete questionnaires Caregivers of individuals with Alzheimer's disease will also complete questionnaires.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study examines how swallowing changes in people with Alzheimer's disease (AD) compared to older adults without dementia. Swallowing difficulties are common but understudied in AD, and this research may help identify early changes and develop better supportive care. **You may be eligible if...** - You are 60 years or older - You have been diagnosed with Alzheimer's disease by a neurologist (with imaging or testing confirmation), OR you are a healthy older adult with no dementia or neurological conditions for the comparison group - You have no prior history of stroke with lasting effects, head/neck cancer, or radiation to the head and neck **You may NOT be eligible if...** - You have other neurological conditions besides Alzheimer's - You have a prior history of throat, esophageal, or swallowing problems unrelated to aging - You are unable to participate in the swallowing assessment procedures Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

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NCT06678100


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