Deep Neuromuscular Blockade on Postoperative Pain
Effect of Deep Neuromuscular Blockade on Postoperative Pain in Pediatric Patients Undergoing Laparoscopic Surgery: a Prospective Randomized Controlled Trial
Seoul National University Hospital
106 participants
Nov 6, 2024
INTERVENTIONAL
Conditions
Summary
This study aims to investigate the impact of varying degrees of neuromuscular blockade on postoperative pain in pediatric patients aged over 2 months to under 7 years undergoing laparoscopic surgery under general anesthesia.
Eligibility
Inclusion Criteria2
- Pediatric patients aged over 2 months to under 7 years scheduled for laparoscopic surgery under general anesthesia.
- American Society of Anesthesiologists (ASA) Physical Status Classification I, II, or III.
Exclusion Criteria6
- Patients undergoing emergency surgery.
- Patients with chronic pain or currently taking analgesics for chronic pain.
- Known hypersensitivity to general anesthetic agents or analgesics.
- Patients with underlying cardiovascular disease.
- Patients with neuromuscular disorders.
- Any other condition that, in the investigator's judgment, would make the patient unsuitable for participation in the study.
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Interventions
To maintain Train-of-four count 1 to 3 during surgery: Administration of continuous infusion of rocuronium at a rate of 0.2 mg/kg/hr to achieve and sustain moderate neuromuscular blockade.
To maintain Train-of-four count 0 during surgery: Administration of continuous infusion of rocuronium at a rate of 0.6 mg/kg/hr to achieve and sustain deep neuromuscular blockade.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06679569