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RecruitingPhase 4NCT06681662

Ephedrine for Reducing Onset Time of Rocurinium in Elderly Patients

A Blinded Randomized Study of Ephedrine 0.15 Mg/kg for Reducing Onset Time of Rocuronium 0.6 Mg/kg in Elderly Patients (≥ 80 Years)

Sponsor

Matias Vested

Enrollment

80 participants

Start Date

Jan 13, 2025

Study Type

INTERVENTIONAL

Conditions

Neuromuscular Blockade

Summary

The aim of this study is to determine the onset time of rocuronium after administration of ephedrine 0.15 mg/kg in patients with age ≥ 80 years. The hypothesis of this study is that ephedrine 0.15 mg/kg provides a shorter onset time compared to placebo (saline).

Eligibility

Min Age: 80 Years

Inclusion Criteria5

  • Age ≥ 80
  • Scheduled for elective operations under general anesthesia with intubation
  • American Society of Anesthesiologists physical status classification (ASA) I to III
  • Informed consent
  • Read and understand Danish

Exclusion Criteria5

  • Known allergy to rocuronium or ephedrine
  • Neuromuscular disease that may interfere with neuromuscular data
  • Indication for rapid sequence induction
  • Daily use of beta-blocking agents
  • Known cardiac arrythmia (atrial fibrillation, supraventricular or ventricular)

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Interventions

DRUGEphedrine Hydrochloride 30 mg/ml

0.15 mg/kg during induction.

DRUGSaline (NaCl 0,9 %) (placebo)

1 ml during induction.

Locations(2)

Department of Anaesthesiology, Pain and Respiratory Support, Rigshospitalet Glostrup

Copenhagen, Denmark

Department of Anesthesia, Centre of Head and Orthopedics, 6013 Rigshospitalet

Copenhagen, Denmark

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