RecruitingPhase 2NCT06686537

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women

Convergent Mechanisms Underlying Reprometabolic Syndrome in Women and Sheep

Sponsor

University of Colorado, Denver

Enrollment

20 participants

Start Date

Feb 25, 2025

Study Type

INTERVENTIONAL

Conditions

Obesity Infertility, Female

Summary

Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.

Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 38 Years

Inclusion Criteria11

Age 18-38
Regular menstrual cycles every 25-35 days
No use of reproductive hormones within the past 3 months
No use of medications interacting with reproductive hormones
Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study
Normal thyroid stimulating hormone, prolactin and lipid profiles
No more than 4 hours of moderate to vigorous intensity exercise per week
No history of chronic disease impacting reproductive hormones
No contraindications to administration of estradiol
No history of estrogen dependent cancer
Negative pregnancy test