RecruitingPhase 3NCT06686771

Radiotherapy to Block Oligoprogression In Metastatic Non-Small-Cell Lung Cancer

Consolidative Use of Radiotherapy to Block (CURB2) Oligoprogression In Patients With Metastatic Non-Small-Cell Lung Cancer

Sponsor

Canadian Cancer Trials Group

Enrollment

320 participants

Start Date

Dec 16, 2025

Study Type

INTERVENTIONAL

Conditions

Non-small Cell Lung Cancer

Summary

This study is being done to answer the following question: Can the chance of lung cancer growing or spreading be lowered by adding targeted radiotherapy to the usual combination of drugs? This study is being done to find out if this approach is better or worse than the usual approach for lung cancer. The usual approach is defined as the care most people get for non-small cell lung cancer.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether adding targeted radiation (SBRT) to the one or two spots where a person's lung cancer is growing again — called "oligoprogression" — while continuing immunotherapy can delay the need to change treatments and extend how long people live. **You may be eligible if...** - You have been diagnosed with stage IV non-small cell lung cancer (NSCLC) without a specific targetable genetic mutation - Your cancer has had limited progression (1–5 sites) after at least 3 cycles of first-line immunotherapy (with or without chemotherapy) - All progressing tumors can safely be targeted with radiation - You are 18 years or older and physically functional (ECOG 0–2) **You may NOT be eligible if...** - Your lung cancer has specific features (e.g., large-cell neuroendocrine, carcinoid, or mixed small cell) - You have leptomeningeal disease (cancer spread to the lining of the brain/spine) - You are pregnant - You have a serious condition that makes radiation unsafe (e.g., scleroderma, interstitial lung disease) - You are currently receiving other experimental anti-cancer treatment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONSBRT

Please refer to the current NCCN NSCLC guidelines for possible treatment options

OTHERFirst or second-line standard of care therapy

Please refer to the current NCCN NSCLC guidelines for possible treatment options.

Locations(57)

City of Hope Comprehensive Cancer Center

Duarte, California, United States

City of Hope at Irvine Lennar

Irvine, California, United States

Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, United States

Saint Luke's Cancer Institute - Boise

Boise, Idaho, United States

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, United States

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, United States

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, United States

Alton Memorial Hospital

Alton, Illinois, United States

Northwestern University

Chicago, Illinois, United States

Decatur Memorial Hospital

Decatur, Illinois, United States

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, United States

Crossroads Cancer Center

Effingham, Illinois, United States

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, United States

Northwestern Medicine Glenview Outpatient Center

Glenview, Illinois, United States

Northwestern Medicine Grayslake Outpatient Center

Grayslake, Illinois, United States

Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, United States

HSHS Saint Elizabeth's Hospital

O'Fallon, Illinois, United States

Northwestern Medicine Oak Brook

Oak Brook, Illinois, United States

Northwestern Medicine Orland Park

Orland Park, Illinois, United States

Memorial Hospital East

Shiloh, Illinois, United States

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, United States

Mercy Hospital

Cedar Rapids, Iowa, United States

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, United States

Miller-Dwan Hospital

Duluth, Minnesota, United States

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, United States

Saint Francis Medical Center

Cape Girardeau, Missouri, United States

Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, United States

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, United States

Washington University School of Medicine

St Louis, Missouri, United States

Siteman Cancer Center-South County

St Louis, Missouri, United States

Siteman Cancer Center at Christian Hospital

St Louis, Missouri, United States

Nebraska Medicine-Bellevue

Bellevue, Nebraska, United States

Nebraska Medicine-Village Pointe

Omaha, Nebraska, United States

University of Nebraska Medical Center

Omaha, Nebraska, United States

Northwell Health/Center for Advanced Medicine

Lake Success, New York, United States

Mount Sinai Chelsea