RecruitingNot ApplicableNCT06688760

Surgery Alone Verus Sugery Combined with Dose-reduced Radiotherapy for Newly Diagnosed Stage I Nasopharyngeal Carcinoma

Endoscopic Nasopharyngectomy Combined with Retropharyngeal Lymph Node Dissection Plus Low-dose Radiotherapy Versus Bilateral Upper Neck Dissection for Newly Diagnosed Stage I Nasopharyngeal Carcinoma: a Randomized Controlled Clinical Trial


Sponsor

Ming-Yuan Chen

Enrollment

86 participants

Start Date

Nov 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to compare the efficacy and safety of endoscopic nasopharyngectomy combined with retropharyngeal lymph nodes dissection plus bilateral upper neck lymph node dissection or plus postoperative low-dose radiotherapy in newly diagnosed stage Ⅰ nasopharyngeal carcinoma.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two treatments for early-stage (Stage I) nasopharyngeal carcinoma — a type of cancer at the back of the nose/throat. It is testing whether surgery alone works just as well as surgery combined with a lower dose of radiation therapy, potentially sparing patients from unnecessary radiation side effects. **You may be eligible if...** - You have been diagnosed with Stage I nasopharyngeal carcinoma (T1N0M0) confirmed by biopsy - Your cancer type is WHO type II or III (non-keratinizing) - You have a good performance status (able to carry out normal activities) - Your blood counts and organ function are within acceptable ranges **You may NOT be eligible if...** - Your cancer has spread beyond Stage I - Your organ function (liver, kidneys, blood counts) is significantly impaired - You are unable to tolerate the planned surgery or radiation Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREEndoscopic nasopharyngectomy combine Retropharyngeal lymphadenectomy and Low Dose Radiotherapy

in experimental arm 1

PROCEDUREEndoscopic nasopharyngectomy combine Retropharyngeal lymphadenectomy and Double upper neck lymph node dissection

in experimental arm 2


Locations(2)

The Fifth Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

The Fifth Affiliated Hospital of Sun Yat-sen University

Zhuhai, Guangdong, China

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NCT06688760


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