How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types
The Acute Effects of an Endurance Exercise Bout the Gut Microbiome and Gut-derived Metabolome in Women's Distinct Fitness and Body Mass Indexes
George Washington University
40 participants
Oct 16, 2024
INTERVENTIONAL
Conditions
Summary
This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows: * Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity. * Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.
Eligibility
Inclusion Criteria4
- Biological sex: female
- BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2
- Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer)
- Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity).
Exclusion Criteria6
- Biological sex: male
- BMI \< 19 kg/m2 or \> 40 kg/m2
- Currently pregnant, \< 2 years postpartum, lactating
- Currently taking any herbal, fiber, or prebiotic supplement
- Current or 1-month before the study, taking oral or vaginal antibiotics
- Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.
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Interventions
30-minute exercise bout in a cycle ergometer at 60 to 70% of the Heart Rate Reserve (HRR) and corresponding power (watts).
Locations(1)
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NCT06691100