Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV

This study is testing whether semaglutide — a medication approved for type 2 diabetes and weight loss (brand name Ozempic/Wegovy) — can also reduce cocaine use in adults with cocaine use disorder, including those living with HIV. Early research suggests GLP-1 drugs like semaglutide may reduce cravings for addictive substances. **You may be eligible if...** - You are 18 or older - You meet the criteria for cocaine use disorder (a pattern of problematic cocaine use) - You have used cocaine at least 7 out of the past 14 days - Your BMI is between 20 and 50 - You can communicate in English - You agree to use effective birth control if you could become pregnant **You may NOT be eligible if...** - You have very high triglyceride levels (above 500 mg/dL) - You have a history of gallbladder disease or pancreatitis - You or a close family member has had a specific type of thyroid cancer (medullary thyroid carcinoma) - You have multiple endocrine neoplasia type 2 (a rare hormonal condition) - You are pregnant or planning to become pregnant Talk to your doctor to see if this trial is right for you.