RecruitingNot ApplicableNCT06697717

End-expiratory Transpulmonary Pressure-guided vs Electrical Impedance Tomography-guided PEEP Titration Methods in Patients With Intra-abdominal Hypertension Combined With Acute Respiratory Distress Syndrome: a Randomized Crossover Controlled Study

End-expiratory Transpulmonary Pressure-guided vs EIT-guided PEEP Titration Methods in Patients With Intra-abdominal Hypertension Combined With Acute Respiratory Distress Syndrome: a Randomized Crossover Controlled Study


Sponsor

XiaoJing Zou,MD

Enrollment

20 participants

Start Date

Jan 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study aims to adopt a randomized crossover design to compare the effects of end-expiratory transpulmonary pressure-guided PEEP titration and EIT-guided PEEP titration on local lung ventilation, shunt, dead space, and ventilation-perfusion (V/Q) ratio as monitored by EIT. Additionally, it will evaluate their impact on respiratory mechanics, chest wall mechanics, mechanical power, hemodynamics, gas exchange, intra-abdominal pressure, abdominal perfusion pressure, and renal perfusion. By identifying an optimal PEEP titration strategy for patients with intra-abdominal hypertension (IAH) and acute respiratory distress syndrome (ARDS), this study aims to develop a mechanical ventilation approach that maintains lung recruitment and minimizes lung injury while avoiding adverse effects on other organs. The findings could facilitate the clinical application of this strategy and benefit a broader population of patients with IAH and ARDS.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is comparing two different methods for setting the breathing machine pressure in critically ill patients on a ventilator who have both high abdominal pressure and a serious lung condition called ARDS (acute respiratory distress syndrome), to see which approach improves oxygen levels more safely. **You may be eligible if...** - You are between 18 and 80 years old - You are in the ICU with increased pressure in your abdomen (12 mmHg or above) - You have been diagnosed with ARDS (a condition where the lungs cannot get enough oxygen into the blood) - Your oxygen levels are severely impaired - You have been on a breathing machine for less than 36 hours **You may NOT be eligible if...** - You are under 18 or over 80 - You have uncontrolled shock from any cause - You have pre-existing lung diseases like COPD or pulmonary fibrosis - Consent from you or your family has not been obtained Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERTranspulmonary Pressure-Guided PEEP Titration in IAH and ARDS Patients

After completion of baseline ventilation and lung recruitment, the ventilator was switched to volume-controlled mode, and PEEP was set using an empirical PL-FiO₂ table, with the goal of maintaining end-expiratory transpulmonary pressure (PL) \> 0 cmH₂O and end-inspiratory PL ≤ 20 cmH₂O.

OTHEREIT-Guided PEEP Titration in IAH and ARDS Patients

After completion of baseline ventilation and lung recruitment, the ventilator was switched to pressure-controlled mode with a pressure control (PC) of 15 cmH₂O. PEEP was initially set at 35 cmH₂O and then gradually decreased in steps of 3 cmH₂O, with each PEEP level maintained for 2 minutes, down to a minimum of 2 cmH₂O, using the ODCL method for PEEP titration.


Locations(1)

Wuhan Union Hospital

Wuhan, Hubei, China

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NCT06697717


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