YN001-004 in Patients With Coronary Atherosclerosis in Australia

Exclusion Criteria28

• Prior treatment with other investigational drug(s) within 30 days or 5 half-lives, whichever is longer, prior to randomization.
• Previously received YN001.
• Any type of vaccination within 4 weeks prior to randomization.
• Contraindication for coronary CTA (e.g., known history of anaphylactic contrast reactions).
• Multi-vessel severe disease.
• Recent acute ST-segment elevation myocardial infarction (STEMI) occurred within 2 weeks prior to randomization.
• Relapse and highly symptomatic arrhythmia uncontrolled by drugs within the past 3 months, such as ventricular tachycardia, atrial fibrillation with rapid ventricular rate and paroxysmal supraventricular tachycardia.
• Prior treatment with CABG, heart transplantation, SAVR/TAVR, etc., or CABG, heart transplantation, SAVR/TAVR, etc., is required or planned during the study.
• PCI performed within 4 weeks prior to randomization or PCI is required or planned during study treatment.
• New York Heart Association (NYHA) class III or IV, or last known left ventricular ejection fraction (LVEF) <40%.
• Recent clinically evident stroke occurred within 6 months prior to randomization (except for TIA).
• Presenting with history of myopathy/myalgia, or susceptible to myopathy/rhabdomyolysis.
• Known inflammatory bowel disease, ulcers, gastrointestinal or rectal bleeding within 6 months prior to randomization.
• Evidence of major diseases that not recovered within 2 weeks prior to randomization, or major surgery is expected during the study.
• Presenting with history of malignancy (except in patients who have been disease-free >5 years; or whose only malignancy has been basal or squamous cell skin carcinoma).
• Presence of any type of autoimmune disease.
• Allergy to multiple food or drugs or known sensitivity to any components to be administered during dosing
• Life expectancy is less than 1 year.
• Systolic blood pressure of ≥150 mmHg at final screening despite antihypertensive therapy.
• Known familial hypercholesterolemia
• Triglycerides≥400 mg/dl (4.5 mmol/l) at final screening.
• Active liver disease or hepatic dysfunction defined by any of ALT, AST, or total bilirubin > 2 times upper limit of normal (ULN) at final screening.
• Presence of renal insufficiency.
• Untreated or inadequately treated hypothyroidism defined by thyroid stimulating hormone (TSH) > 1.5 times ULN at final screening.
• Poorly controlled (defined by HbA1c > 9%) type 2 diabetes mellitus.
• A positive hepatitis B surface antigen (HBsAg), or positive antibody against hepatitis C virus (anti-HCV) or human immunodeficiency virus (anti-HIV), or positive treponema pallidum antibody (TP-Ab).
• Current smoker who has smoked an average of≥5 cigarettes (or equivalent) per day over the preceding year.
• Presence of any other diseases or conditions (apart from those outlined above) that, in the opinion of the investigator, would make it unsuitable for the patient to participate in this study.