RecruitingPhase 2NCT06700720

YN001-004 in Patients With Coronary Atherosclerosis in Australia

A Phase Ⅱa Clinical Study to Evaluate the Efficacy and Safety of YN001 in Patients With Coronary Atherosclerosis in Australia


Sponsor

Beijing Inno Medicine Co., Ltd.

Enrollment

24 participants

Start Date

Feb 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is to evaluate the efficacy and safety of intravenously administered YN001 in patients with coronary atherosclerosis in Australia. This study will be conducted in eligible participants with a diagnosis of coronary atherosclerosis, and at least 1 coronary artery is blocked determined by coronary computed tomography angiography (CCTA)


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Dose 1 YN001, a drug called Dose 2 YN001, and others for people with coronary artery disease and coronary atherosclerotic disease. The study is currently recruiting participants at 7 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDose 1 YN001

Dose 1 YN001 will be administered on Day 1 of each week from Week 1 to Week 13, 13 times in total.

DRUGDose 2 YN001

Dose 2 YN001 will be administered on Day 1 of each week from Week 1 to Week 13, 13 times in total.

DRUGEvolocumab

Evolocumab 140 mg will be administered subcutaneously every 2 weeks.


Locations(7)

Canberra Hospital

Canberra, Australian Capital Territory, Australia

Albury Wodonga Private Hospital

Albury, New South Wales, Australia

Sunshine Coast University Private Hospital

Birtinya, Queensland, Australia

Core Research Group Pty Ltd

Milton, Queesland, Australia

Altona Clinical Research

Melbourne, Victoria, Australia

Peninsula Heart Centre

Melbourne, Victoria, Australia

John Flynn Private Hospital

Tugun, Australia

View Full Details on ClinicalTrials.gov

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NCT06700720


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