RecruitingNCT06700876

Evaluation of IGRA, Symptoms and Chest Radiograph for Subclinical TB Detection in ESRD and KT

Evaluation of Interferon-gamma Release Assays, Symptom Screening and Chest Radiograph for Detection of Subclinical Tuberculosis of End-stage Kidney Disease and Kidney Transplant Recipients in Thailand

Sponsor

Mahidol University

Enrollment

160 participants

Start Date

Aug 6, 2024

Study Type

OBSERVATIONAL

Conditions

Tuberculosis (TB)

Summary

This is an observational study among approximately 160 end-stage renal disease patients on renal replacement therapy and post-living donor or deceased donor kidney transplant recipients. Investigators aim to assess the proportion of positive IGRA associated with symptom development, sputum Xpert MTB/RIF assay, and chest radiograph to define latent TB infection and subclinical TB among ESKD and renal transplant patients.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating the best combination of tests to detect hidden (subclinical) tuberculosis (TB) infection in people with severe kidney disease or those who have had a kidney transplant, since these patients are at higher risk for TB. **You may be eligible if...** - You have end-stage kidney disease and are on dialysis (hemodialysis or peritoneal dialysis) - Or you have received a kidney transplant (living or deceased donor) - You are 18 or older **You may NOT be eligible if...** - You have already tested positive for TB (via a PPD/tuberculin skin test) in the past - You currently have active TB infection in the lungs or elsewhere in the body Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Locations(1)

Vaccine Trial Centre, Faculty of Tropical Medicine, Mahidol University

Bangkok, Thailand

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NCT06700876

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