Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery
Columbia University
36 participants
Dec 6, 2024
INTERVENTIONAL
Conditions
Summary
The proposed study seeks to understand how the cervical spinal cord should be stimulated after injury through short-term physiology experiments that will inform a preclinical efficacy trial. The purpose of this study is to determine which cervical levels epidural electrical stimulation (EES) should target to recruit arm and hand muscles effectively and selectively in spinal cord injury (SCI).
Eligibility
Inclusion Criteria1
- •Clinical indication for cervical spine surgery.
Exclusion Criteria1
- •Stimulation devices in the neck or chest (e.g., vagal nerve stimulation, cardiac patients with pacemakers)
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Interventions
The surgeon will place spinal cord electrodes on the epidural surface, with stimulation sites identified using preoperative MRI. Recruitment curves will be generated by systematically increasing the stimulation intensity across various parameter combinations, including frequency, pulse count, pulse shape, and electrode-specific properties such as size, separation, and arrangement.
Locations(2)
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NCT06701422