RecruitingEarly Phase 1NCT06702631

Nitrous Oxide Neuroimaging

Functional MRI of Nitrous Oxide Inhalation in Volunteer Subjects

Sponsor

Keith M Vogt

Enrollment

60 participants

Start Date

Jan 13, 2025

Study Type

INTERVENTIONAL

Conditions

Pain Anesthesia Amnesia

Summary

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Eligibility

Min Age: 18 YearsMax Age: 59 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Nitrous oxide and a medical device called Peripheral Nerve Stimulation for people with amnesia, anesthesia, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 59 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNitrous oxide

After a no-drug control period, subjects will inhale nitrous oxide, administered via a breathing circuit and face mask, until a steady-state target end-tidal expired concentration is reached. During the drug condition, subjects will receive low-dose nitrous oxide (% corresponding to Minimum Alveolar Concentration).

DEVICEPeripheral Nerve Stimulation

Experimental acute pain stimulus will be delivered using a nerve stimulator. These painful shocks will be paired with a fixed number of the experimental cues, in a pattern that appears random to participants.