RecruitingEarly Phase 1NCT06702631

Nitrous Oxide Neuroimaging

Functional MRI of Nitrous Oxide Inhalation in Volunteer Subjects

Sponsor

Keith M Vogt

Enrollment

60 participants

Start Date

Jan 13, 2025

Study Type

INTERVENTIONAL

Conditions

Pain Anesthesia Amnesia

Summary

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Eligibility

Min Age: 18 YearsMax Age: 59 Years

Exclusion Criteria20

have a valid email address and valid phone number throughout the study
free from any non-MRI compatible implants
are pregnant or attempting to conceive
body mass index (BMI) > 35
significant memory impairment or hearing loss
sleep apnea
chronic pain or frequently taking pain medication (including tramadol)
any severe or poorly-controlled medical problem (hypertension, diabetes)
neurologic or psychiatric disease, including anxiety, and depression
severe cardiac disease
history of methylenetetrahydrofolate reductase (MTHFR) deficiency or variant mutation, as assessed by personal report
recent ear or eye surgery
being claustrophobic
have metal implants or non-removable metal piercings
having a history of adverse reaction to anesthetics
daily alcohol or heavy alcohol use; history of alcohol abuse
current daily smoker
regular or recent marijuana use (including prescribed/medical marijuana)
illicit drug use, i.e., street drugs
regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids

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Interventions

DRUGNitrous oxide

After a no-drug control period, subjects will inhale nitrous oxide, administered via a breathing circuit and face mask, until a steady-state target end-tidal expired concentration is reached. During the drug condition, subjects will receive low-dose nitrous oxide (% corresponding to Minimum Alveolar Concentration).

DEVICEPeripheral Nerve Stimulation

Experimental acute pain stimulus will be delivered using a nerve stimulator. These painful shocks will be paired with a fixed number of the experimental cues, in a pattern that appears random to participants.