RecruitingPhase 4NCT06706284

Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes


Sponsor

Marzieh Salehi

Enrollment

50 participants

Start Date

Apr 11, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

It is not known whether a new diabetes drug, semaglutide, is an effective treatment for type 2 diabetes for persons with spinal cord injury (SCI), a population at higher risk for this condition. Therefore, this study looks at the effect of semaglutide on glucose levels in the body and other information about type 2 diabetes and obesity.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether GLP-1 receptor agonists — the class of drugs that includes medications like semaglutide (Ozempic/Wegovy) — can improve blood sugar control and support weight loss in people who have a spinal cord injury and Type 2 diabetes. **You may be eligible if...** - You are between 18 and 70 years old - You had a spinal cord injury more than one year ago (injury level between C2 and L2) - You have Type 2 diabetes managed with diet and metformin only (no major dose changes in the last 3 months) - Your HbA1c (average blood sugar) is between 6.0% and 9.0% - Your BMI is over 22 **You may NOT be eligible if...** - You are on insulin or other diabetes medications besides metformin - You have Type 1 diabetes - You are pregnant or planning to become pregnant - You have conditions that make this class of medication unsafe Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGSemaglutide Injectable Product

A GLP-1 inhibitor used to control T2DM

OTHERPlacebo

Saline solution will be administered with the same frequency as semaglutide and participants will be instructed how to use the saline in the same manner as the active drug group.


Locations(2)

University Health - Texas Diabetic Institute

San Antonio, Texas, United States

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06706284


Related Trials