Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients

This study is testing whether metformin — a commonly used diabetes drug with anti-inflammatory properties — can improve outcomes when added to standard antidepressant treatment in obese patients newly diagnosed with depression. **You may be eligible if...** - You are between 18 and 45 years old - You are male or female with a BMI over 25 (overweight or obese) - You have been newly diagnosed with depression (mild to severe) - You do not have diabetes (HbA1c below 5.7%) **You may NOT be eligible if...** - You have diabetes or pre-diabetes - You have had a recent kidney injury, heart attack, or liver injury - You have chronic kidney disease - You have an intellectual disability or serious psychiatric condition other than depression - You have taken any psychiatric medication in the past 6 months Talk to your doctor to see if this trial is right for you.