RecruitingNCT06707519

NSCLC Liquid Biopsies and Exhaled VOC

A Prospective, Single Center Study to Test the Validity and Feasibility of Circulating Tumor DNA in Blood, Sputum and Alveolar Fluid, as Well as Exhaled Volatile Organic Compounds as Biomarkers in Non-Small Cell Lung Cancer

Sponsor

St. Joseph's Healthcare Hamilton

Enrollment

210 participants

Start Date

Feb 1, 2023

Study Type

OBSERVATIONAL

Conditions

Lung Cancer Circulating Tumor DNA

Summary

The objective of the study is to determine the feasibility of recruiting participants and using sputum, Bronchoalveolar lavage (BAL) and exhaled Volatile Organic Compounds (VOC) in addition to blood, as biological samples for detecting mutations in extracted cell-free DNA in non-small cell lung cancer (NSCLC) patients, before and after surgery, and any recurrence within a 24-month postoperative follow-up period. This is a pilot feasibility study, proposed as a 24-month prospective, single-center, non-interventional, observational trial with NSCLC-adenocarcinoma patients indicated for resection surgery with curative intent.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is collecting blood samples and breath samples from people undergoing surgery to remove non-small cell lung cancer (NSCLC) to see whether circulating tumor DNA in blood and volatile organic compounds in breath can serve as biomarkers to detect and monitor lung cancer. **You may be eligible if...** - You are at least 18 years old - You are having lung surgery with curative intent for non-small cell lung cancer at a participating hospital **You may NOT be eligible if...** - Your surgery is for palliative (non-curative) purposes, or you have metastatic lung cancer - You have another active cancer - You have been treated for a different cancer within the past 5 years (excluding non-melanoma skin cancer) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.