RecruitingPhase 3NCT06708299

CardiolRx in Recurrent Pericarditis (MAVERIC Phase-3)

CardiolRxTM in Recurrent Pericarditis (MAVERIC Phase 3) A Randomized, Double-blind, Placebo-controlled Trial


Sponsor

Cardiol Therapeutics Inc.

Enrollment

110 participants

Start Date

Apr 7, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

Multi-center, randomized, double-blind, placebo-controlled, phase-3 Trial. Patients with a history of recurrent pericarditis who are being treated with an IL-1 blocker for at least 12 months, scheduled to be discontinued, will be approached for potential trial participation. Double-blind treatment will be initiated 10 - 16 days prior to the last scheduled dose of the IL-1 blocker and continued for 24 weeks. The objective is to assess whether patients remain free of pericarditis recurrence while receiving CardiolRx.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called CardiolRx for people with recurrent pericarditis. The study is currently recruiting participants at 27 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCardiolRx

The intervention will be administered orally (via syringe) with food twice daily.


Locations(27)

Mayo Clionic Arizona

Phoenix, Arizona, United States

UCI Health

Irvine, California, United States

Altman Clinical and Translational Research Institute

La Jolla, California, United States

Cedars-Sinai Medical Center

Los Angeles, California, United States

Pacific Heart Institute at Cedars-Sinai

Santa Monica, California, United States

Mayo Clinic Florida

Jacksonville, Florida, United States

Northwestern University

Chicago, Illinois, United States

Johns Hopkins University

Baltimore, Maryland, United States

MedStar Health Institute

Columbia, Maryland, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Minneapolis Heart Institute

Minneapolis, Minnesota, United States

Mayo Clinic

Rochester, Minnesota, United States

NYU Langone Health

New York, New York, United States

Columbia University - New York Presbyterian

New York, New York, United States

Lenox Hill Hospital

New York, New York, United States

Cleveland Clinic

Cleveland, Ohio, United States

Houston Methodist Hospital

Houston, Texas, United States

University of Utah Hospital

Salt Lake City, Utah, United States

University of Vermont

Burlington, Vermont, United States

University of Virginia

Charlottesville, Virginia, United States

Virginia Commonwealth University

Richmond, Virginia, United States

Jewish General Hospital

Montreal, Canada

Hippokration General Hospital

Athens, Greece

Fatebenefratelli Hospital Milano

Milan, Italy

University of Padua

Padua, Italy

University Hospital

Torino, Italy

University Hospital Udine

Udine, Italy

View Full Details on ClinicalTrials.gov

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NCT06708299


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