Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesions
Clinical Outcome of Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesion - a Randomized Clinical Trial
October 6 University
150 participants
Aug 30, 2024
INTERVENTIONAL
Conditions
Summary
Clinical assessment of the effectiveness of two treatment modalities (self-assembling peptide (P11-4) (alone or combined with fluoride) and resin infiltration) for treating white spot lesions
Eligibility
Inclusion Criteria5
- Age (a range from 7-14 years of age was determined)
- Good general health (absence of disease/no handicaps, to ensure oral care at home)
- Preserved pulp vitality of the teeth.
- Consolidated oral care daily.
- Agreement by patient and parents (or guardians) to participate in the study
Exclusion Criteria3
- Patients with periodontal diseases (periodontal pockets or dental mobility) or radiologically identified pathologies (periapical radiolucency).
- Teeth revealing any restorations were excluded from the current study.
- Any previous or planned WSL treatment.
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Interventions
rationally designed peptide, the monomers of which self-assemble into a biocompatible fibrillar scaffold that mimics the enamel matrix in response to particular environmental cues
self assembling peptide with 500 ppm sodium fluoride
Improvement of white spot lesions appearance by infiltration occurs due to a change in the refractive index since the refractive index of enamel (1.62-1.65) is different than that of air (1.00). Infiltration of the lesions with an infiltrate that has a refractive index of 1.52 is able to mask the lesion
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06708481