White Spot Lesion Clinical Trials

11 recruitingLast updated: May 21, 2026

There are 11 actively recruiting white spot lesion clinical trials across 9 countries. Studies span Not Applicable, Early Phase 1, Phase 2, Phase 4. Top locations include Al Mansurah, Egypt, Baghdad, Iraq, Baltimore, Maryland, United States. Updated daily from ClinicalTrials.gov.


White Spot Lesion Trials at a Glance

11 actively recruiting trials for white spot lesion are listed on ClinicalTrialsFinder across 6 cities in 9 countries. The largest study group is Not Applicable with 6 trials, with the heaviest enrollment activity in Al Mansurah, Baghdad, and Baltimore. Lead sponsors running white spot lesion studies include Dow University of Health Sciences, Heba Tahseen Almasri, and Catherine Giannopoulou.

Browse white spot lesion trials by phase

About White Spot Lesion Clinical Trials

Looking for clinical trials for White Spot Lesion? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new White Spot Lesion trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about White Spot Lesion clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 111 of 11 trials

Recruiting
Not Applicable

Air-polishing With Erythritol During Orthodontic Tretament

Inflammation GumWhite Spot Lesion
Catherine Giannopoulou60 enrolled1 locationNCT05989750
Recruiting
Not Applicable

Effect of Hydroxyapatite Toothpaste and Mouthwash in Preventing White Spot Lesions During Orthodontic Treatment

Prevention of White Spot Lesions in Patients Undergoing Orthodontic Treatment
Heba Tahseen Almasri75 enrolled1 locationNCT07325643
Recruiting
Not Applicable

A Split-Mouth Clinical Trial Evaluating the Bond Failure Rate of a New Etch-Free Orthodontic Adhesive

Bracket BondingOrthodontic TreatmentDental Adhesives/Restorations Performance+1 more
University of Maryland, Baltimore20 enrolled1 locationNCT07091422
Recruiting
Not Applicable

Clinical Evaluation of Remineralizing Potential of Remineralizing Agents on WSLs Managment

White Spot Lesion of ToothInitial Dental Caries
Mansoura University120 enrolled1 locationNCT07111403
Recruiting
Not Applicable

Comparison of MI Paste Plus and Resin Infiltration in White Spot Lesions Following Orthodontic Treatment

White spot lesionsOrthodontic Appliance ComplicationCaries Arrested+1 more
University of Alberta62 enrolled1 locationNCT05733676
Recruiting
Phase 4

A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome

Dental CariesWhite Spot LesionInitial Caries+1 more
Dow University of Health Sciences90 enrolled1 locationNCT06172764
Recruiting
Early Phase 1

Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesions

White Spot Lesion
October 6 University150 enrolled1 locationNCT06708481
Recruiting
Phase 2

Topical 10% Povidone-Iodine in Preventing White Spots

White spot lesionsGingival Inflammation and Bleeding
University of Washington80 enrolled1 locationNCT06616207
Recruiting
Early Phase 1

Remineralizing Effect of Different Silver-containing Agents on Initial Caries Lesions in Primary Teeth in Children

White Spot Lesion of Tooth
Plovdiv Medical University30 enrolled1 locationNCT06489093
Recruiting
Not Applicable

Color Masking Potential of Bioactive and ICON Materials

White Spot Lesion of Tooth
King Abdullah University Hospital75 enrolled1 locationNCT06402500
Recruiting

Comparison of the oral microorganisms between patients being treated with orthodontic brackets or aligners.

GingivitisWhite spot lesions
University of Melbourne, School of Dentistry120 enrolled1 locationACTRN12617000925347