RecruitingPhase 3NCT06711185

Effect of DAPAglifozin on MYOcardial Remodeling of Breast CANCER Patients Treated with Anthracycline Based Chemotherapy


Sponsor

University of Campinas, Brazil

Enrollment

80 participants

Start Date

Jan 30, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Prospective, randomized, double-blind, controlled clinical trial to compare the effect of 9 months of treatment with dapagliflozin vs. placebo on anthracycline-induced cardiotoxicity in patients with breast cancer.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether a diabetes medication called dapagliflozin (an SGLT2 inhibitor) can protect the heart from damage caused by anthracycline-based chemotherapy (a common breast cancer treatment known to affect heart function). **You may be eligible if...** - You are a woman over 18 years old with breast cancer - You are scheduled to receive anthracycline chemotherapy (equivalent to at least 240 mg/m² of doxorubicin) **You may NOT be eligible if...** - You have a pacemaker, defibrillator, certain metal implants, or cochlear implant (which would prevent MRI scans) - You have claustrophobia that prevents MRI - You have severe kidney disease (very low filtration rate) - You have a history of heart attack, heart failure, heart surgery, or significant heart valve or muscle disease Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDapagliflozin 10 mg

Patients in this group will receive 1 tablet of 10mg dapagliflozin daily for 9 months, starting 7-10 days before chemotherapy treatment.

OTHERPlacebo

Patients in this group will receive 1 placebo tablet per day, with identical characteristics to the group receiving dapagliflozin, for 9 months, starting 7-10 days before the start of chemotherapy treatment


Locations(1)

Hospital de Clinicas da Unicamp

Campinas, São Paulo, Brazil

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NCT06711185


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