Extracellular Vesicles in Fibrin Gel for Cartilage Repair
Fibrin Gel Loaded with Extracellular Vesicles for the Treatment of Cartilage Lesions in the Joints - GelVex Study
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
51 participants
Oct 29, 2024
OBSERVATIONAL
Conditions
Summary
This project aims to produce and study in vitro/ex vivo a platelet rich plasma (PRP)-derived fibrin gel loaded with mesenchymal stromal cells (MSC)-extracellular vesicles (EVs), to combine the positive results on cartilage growth of PRP growth factors and the hyaline cartilage stimulating activity of MSC-EVs. Therefore, the project goal is to provide an advanced option for orthopedic patients with an innovative evolution of a gold standard procedure, making it easy to translate into daily clinical practice for physicians, healthcare professionals and patients.
Eligibility
Inclusion Criteria5
- males and females ≥ 18
- patients undergoing plastic surgery procedures;
- patients undergoing elective joint surgery with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade);
- patients undergoing regenerative medicine treatments with PRP with a diagnosis of knee or hip osteoarthritis (any Kellgren-Lawrence grade;
- signed Informed Consent for the study
Exclusion Criteria3
- Positive virological test (HIV, HCV, HBV, TPHA)
- Pregnancy or breastfeeding by self-declaration
- Other conditions that, at the discretion of the investigator or the physician
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Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06713902