Evaluating the Efficacy and Patient Experience of Catheter-Free Intravesical Instillation

This study is testing a new way to deliver medication directly into the bladder without using a catheter. Traditionally, bladder instillation requires inserting a tube (catheter) into the urethra, which can be uncomfortable. This study evaluates whether a catheter-free method is equally effective and more comfortable for patients. **You may be eligible if...** - You are between 18 and 80 years old - Your doctor has determined you need bladder medication for one of the following conditions: interstitial cystitis (painful bladder syndrome), recurrent urinary tract infections, non-muscle invasive bladder cancer, post-radiation cystitis, or post-chemotherapy cystitis - You had a negative urine culture within the last two weeks (no current infection) - You have given consent to participate **You may NOT be eligible if...** - You have an active urinary tract infection or had one within the past month - You have a bleeding disorder or frequent visible blood in your urine - You retain more than 100 mL of urine after urinating - You have a mental condition that prevents reliable cooperation Talk to your doctor to see if this trial is right for you.