RecruitingPhase 1NCT06719427

qEEG Brain Signature of Depression & Neuromodulation-induced Recovery

Quantitative Electroencephalography to Longitudinally Assess the Functional Brain Signature of Treatment-resistant Depression and Recovery With Therapeutic Neuromodulation

Sponsor

Sunnybrook Health Sciences Centre

Enrollment

100 participants

Start Date

Jan 6, 2025

Study Type

INTERVENTIONAL

Conditions

Major Depressive Diorder

Summary

This study aims to explore how repetitive transcranial magnetic stimulation (rTMS), a treatment for depression, affects brain function. Depression disrupts the brain's complex network or regions that regulate cognition, emotion, and behavior. rTMS targets these disruptions to restore network function. To measure these effects, researchers will use dry quantitative EEG (qEEG), a new technology that records brain electrical activity quickly (15 minutes compared to 1 hour for traditional EEG) without the need for gel or lengthy electrode setups. This study will evaluate a novel qEEG activity developed by iMediSync (Republic of South Korea) in patients treated with neuromodulation for depression before, during, and up to 12 months after treatment to see if changes in brain activity to identify patterns associated with symptomatic improvement and relapse risk. Findings could help personalize depression treatments by predicting patient outcomes and optimizing care.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at brain wave patterns in people with depression who are receiving a type of brain stimulation therapy called repetitive transcranial magnetic stimulation (rTMS). Researchers want to identify EEG (brainwave) signatures that can predict who will respond well to this treatment, and track brain changes during recovery. **You may be eligible if...** - You have a diagnosis of depression based on standard medical criteria (DSM-5) - You are currently receiving rTMS treatment for depression at the study center - You are between 18 and 80 years old - You are generally physically healthy - You are able to give informed consent and follow the study procedures - Non-English speakers are welcome unless a language barrier relates to a medical exclusion **You may NOT be eligible if...** - You have a moderate-to-severe substance use disorder - You have significant other medical conditions such as neurological disease, uncontrolled high blood pressure or diabetes, or cancer - You have a serious psychiatric condition like schizophrenia or bipolar disorder, or are currently experiencing psychosis - You have a history of seizures - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DEVICETranscranial Magnetic Stimulation

rTMS is a non-invasive brain stimulation that uses magnetic fields to stimulate specific areas of the brain. It is commonly used for the treatment of neurological and psychiatric disorders, such as major depressive disorder (MDD), anxiety, and sometimes ALS.