RecruitingNot ApplicableNCT06721078

Evaluation of Long-Acting Injectable (LAI) and Teen Clubs in Adolescents (ATTUNE).


Sponsor

Africa Health Research Institute

Enrollment

720 participants

Start Date

Feb 9, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This is a 2-stage study assessing the effect of peer navigation (support from peers) and long-acting injectable antiretroviral therapy (ART) on viral suppression and retention in care among adolescents living with HIV and receiving care in South Africa.


Eligibility

Min Age: 12 YearsMax Age: 19 Years

Inclusion Criteria9

  • Aged between 12 - <19, at enrolment
  • Living with HIV
  • Aware of their HIV status
  • Receiving ART for at least six months
  • Able to read and/or speak English, isiZulu, Sepedi, Afrikaans, Xhosa, or Sesotho
  • Willing and able to consent to study activities
  • Willing and able to get parental consent for study activities
  • (Stage 1, objective 2 only) Age ≥ 18 years and Caregiver of an adolescent with HIV
  • (Stage 1, objective 2 only) Age ≥ 18 years and provides clinical services or is a policy maker involved in adolescents with HIV

Exclusion Criteria2

  • Inability to read and/or speak English, isiZulu, Sepedi, Afrikaans, Xhosa, or Sesotho
  • Severe mental or physical illness preventing participation in informed consent activities.

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Interventions

BEHAVIORALPeer navigation effectiveness

To determine the effectiveness of peer navigation on viral suppression and retention in care among adolescents living with HIV in South Africa.


Locations(12)

Charlotte Maxeke Hospital

Johannesburg, Gauteng, South Africa

Rahima Moosa Mother and Child Hospital

Johannesburg, Gauteng, South Africa

Kgabo CHC

Pretoria, Gauteng, South Africa

KT Motubatse CHC

Pretoria, Gauteng, South Africa

Soshanguve Block JJ

Pretoria, Gauteng, South Africa

Soshanguve Block TT

Pretoria, Gauteng, South Africa

Cato Manor CHC

Durban, KwaZulu-Natal, South Africa

KwaMashu CHC

Durban, KwaZulu-Natal, South Africa

Mtubatuba CHC

Mtubatuba, KwaZulu-Natal, South Africa

Somkhele CHC

Mtubatuba, KwaZulu-Natal, South Africa

Eerste River Hospital

Cape Town, Western Cape, South Africa

Michael Mapongwana CHC

Cape Town, Western Cape, South Africa

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NCT06721078


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