Effects of Intravenous Metabolic Recovery Agent in Elderly Septic Patients on Prognosis and Microcirculation.
Clinical Study of the Effect of Intravenous Hydrocortisone Combined With Vitamin C and Vitamin B1 Infusion on Prognosis and Sublingual Microcirculation in Elderly Patients With Sepsis or Septic Shock.
Southeast University, China
40 participants
Jul 1, 2024
INTERVENTIONAL
Conditions
Summary
This study intends to observe the effect of intravenous hydrocortisone combined with vitamin C and vitamin B1 infusion on the prognosis and sublingual microcirculation in patients with sepsis or septic shock through a prospective randomized controlled study method.
Eligibility
Inclusion Criteria4
- Age ≥60 and ≤85 years old;
- Diagnosis of sepsis or septic shock;
- Clinical judgment for hydrocortisone treatment;
- Signing Informed Consent.
Exclusion Criteria7
- patients in palliative care;
- uncontrolled malignancy with multiple metastases;
- ineffective surgical intervention for the infectious agent;
- estimated death within 24 hours;
- glucocorticoids used in the last 7 days;
- allergy to hydrocortisone, vitamin c or vitamin B1;
- inability to measure sublingual microcirculation.
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Interventions
Intervention group will receive intravenous hydrocortisone (200mg every 24 hours), vitamin C (1.5g every 6 hours), and thiamine (200 mg every 12 hours).
Placebo group will receive intravenous hydrocortisone 200mg every 24 hours.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06723626