Septic Shock Clinical Trials

96 recruitingLast updated: May 4, 2026

Septic Shock Trials at a Glance

94 actively recruiting trials for septic shock are listed on ClinicalTrialsFinder across 6 cities in 39 countries. The largest study group is Not Applicable with 30 trials, with the heaviest enrollment activity in Paris, Amiens, and Cairo. Lead sponsors running septic shock studies include Centre Hospitalier Universitaire, Amiens, Assistance Publique - Hôpitaux de Paris, and Ain Shams University.

Browse septic shock trials by phase

Treatments under study

About Septic Shock Clinical Trials

Looking for clinical trials for Septic Shock? There are currently 96 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Septic Shock trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Septic Shock clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 94 trials

Recruiting
Not Applicable

Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock

Septic ShockSepsis - to Reduce Mortality in the Intensive Care Unit
University Hospital, Clermont-Ferrand750 enrolled27 locationsNCT07179276
Recruiting
Not Applicable

Early Norepinephrine Administration and Rapid Dose Adjustment

SepsisSeptic Shock
Siriraj Hospital600 enrolled6 locationsNCT07343206
Recruiting

Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients

Septic Shock
Ain Shams University40 enrolled1 locationNCT07550400
Recruiting
Phase 3

Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation

PneumoniaSeptic ShockThe Critically Ill Patient is Requiring Intubation
Helwan University41 enrolled1 locationNCT07530146
Recruiting

In Vivo Antibiotics Removal During Hemoadsorption Cartridges and Continuous Renal Replacement Therapy in the Intensive Care Unit

Septic Shock
Niguarda Hospital20 enrolled1 locationNCT07230041
Recruiting

Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study

SepsisSeptic ShockMultiorgan Failure
Seoul National University Bundang Hospital360 enrolled1 locationNCT07539883
Recruiting
Phase 2

Study SOLACE SEPSIS

Septic ShockIntracranial Hypertension
University Hospital Pilsen40 enrolled1 locationNCT06634069
Recruiting
Not Applicable

Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically Ill Patients

SepsisSeptic ShockAcute Skin Failure
Ying Wang216 enrolled1 locationNCT07367113
Recruiting

The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock

Septic Shock
Avicenna Military Hospital30 enrolled3 locationsNCT07096284
Recruiting
Not Applicable

Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis

Septic Shock
University of Oklahoma34 enrolled1 locationNCT03992378
Recruiting
Not Applicable

Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients

Septic Shock
Region Skane1,850 enrolled22 locationsNCT06140147
Recruiting
Phase 2Phase 3

Early Methylene Blue in the Microhemodynamics of Septic Patients

HypoperfusionSeptic Shock
Centro de Estudos e Pesquisa em Emergencias Medicas e Terapia Intensiva50 enrolled1 locationNCT07264543
Recruiting

Sepsis: From Syndrome to Personalized Care

SepsisSeptic ShockSepsis, Severe+1 more
Oslo University Hospital1,950 enrolled1 locationNCT04203979
Recruiting

Study on the Efficacy and Timing of ECMO Therapy in Children With Refractory Septic Shock

Septic ShockExtracorporeal Membrane Oxygenation Complication
Children's Hospital of Fudan University60 enrolled1 locationNCT03948048
Recruiting
Phase 4

Early Versus Late Adjunctive Vasopressin in Septic Shock

SepsisSeptic Shock
The Cleveland Clinic300 enrolled1 locationNCT06709573
Recruiting
Phase 4

Early Angiotensin II in the Emergency Department

Septic Shock
Brett A Faine20 enrolled1 locationNCT06693726
Recruiting
Phase 4

Hydrocortisone and Fludrocortisone for the Treatment of Septic Shock

Septic Shock
Northern Jiangsu People's Hospital336 enrolled1 locationNCT07383103
Recruiting

OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study

SepsisSeptic ShockBlood Purification+1 more
Pauls Stradins Clinical University Hospital29 enrolled1 locationNCT07419802
Recruiting
Not Applicable

External Drainage of Thoracic Duct Lymph to Reduce Inflammatory Cytokines in Septic Shock Patients

SepsisSeptic Shock
University of Pennsylvania10 enrolled1 locationNCT04855786
Recruiting

Identification of Markers of Poor Clinical Prognosis in Sepsis by Epigenetic Analysis

SepsisSeptic ShockSepsis Syndrome
Assistance Publique Hopitaux De Marseille25 enrolled1 locationNCT06446947