Septic Shock Clinical Trials

106 recruitingLast updated: June 18, 2026

There are 106 actively recruiting septic shock clinical trials across 41 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3. Top locations include Paris, France, Amiens, France, Cairo, Egypt. Updated daily from ClinicalTrials.gov.


Septic Shock Trials at a Glance

106 actively recruiting trials for septic shock are listed on ClinicalTrialsFinder across 6 cities in 41 countries. The largest study group is Not Applicable with 32 trials, with the heaviest enrollment activity in Paris, Amiens, and Cairo. Lead sponsors running septic shock studies include Centre Hospitalier Universitaire, Amiens, Assistance Publique - Hôpitaux de Paris, and Ain Shams University.

Browse septic shock trials by phase

Treatments under study

About Septic Shock Clinical Trials

Looking for clinical trials for Septic Shock? There are currently 104 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Septic Shock trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Septic Shock clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 106 trials

Recruiting

Does Urinary TIMP2 and IGFBP7 Can Identify High Risk Patients of Progression From Mild and Moderate to Severe Acute Kidney Injury During Septic Shock?

Acute Kidney InjurySeptic Shock
Centre Hospitalier Universitaire, Amiens110 enrolled1 locationNCT03547414
Recruiting

TIMP2*IGFBP7 and Transient AKI

Septic Shock
Centre Hospitalier Universitaire, Amiens190 enrolled1 locationNCT03472079
Recruiting
Not Applicable

Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock

Septic ShockSepsis - to Reduce Mortality in the Intensive Care Unit
University Hospital, Clermont-Ferrand750 enrolled28 locationsNCT07179276
Recruiting
Phase 2

Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis

SepsisSeptic ShockPeritonitis
RWTH Aachen University200 enrolled20 locationsNCT03334006
Recruiting
Phase 4

Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure

Acute Respiratory FailureKidney Transplant RecipientsSepsis and septic shock+1 more
University Hospital, Strasbourg, France212 enrolled1 locationNCT06881927
Recruiting

MIRNA QUANTIFICATION IN PATIENTS WITH SEPTIC SHOCK

Sepsis and septic shock
Insel Gruppe AG, University Hospital Bern56 enrolled1 locationNCT07597122
Recruiting
Phase 2

Adjunctive Fludrocortisone in Septic Shock

SepsisSeptic ShockSepsis and septic shock+2 more
Chinese University of Hong Kong32 enrolled5 locationsNCT07451886
Recruiting
Phase 3

Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation

PneumoniaSeptic ShockThe Critically Ill Patient is Requiring Intubation
Helwan University41 enrolled2 locationsNCT07530146
Recruiting
Not Applicable

Focused Ultrasound Spleen Stimulation and Inflammation in Septic Shock

Septic ShockCritical CareFocused Ultrasound+2 more
First Affiliated Hospital of Wannan Medical College40 enrolled1 locationNCT06990295
Recruiting

Cortisol Levels and Mortality in Septic Shock ICU Patients

SepsisSeptic Shock
Ankara Etlik City Hospital183 enrolled1 locationNCT07582926
Recruiting

Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Age Admitted to Intensive Care for Septic Shock.

FrailtySeptic Shock
Centre Hospitalier de Lens200 enrolled5 locationsNCT05928767
Recruiting

Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey

SepsisSeptic ShockCritical Illness+1 more
Marmara University2,500 enrolled1 locationNCT07300306
Recruiting
Not Applicable

Early Norepinephrine Administration and Rapid Dose Adjustment

SepsisSeptic Shock
Siriraj Hospital600 enrolled6 locationsNCT07343206
Recruiting

Role of Echocardiography and Ultrasound Indices in Resuscitation of Septic Shock Patients

fluid resuscitationSeptic Shock
Ain Shams University40 enrolled1 locationNCT07550400
Recruiting

Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study

SepsisSeptic ShockMultiorgan Failure
Seoul National University Bundang Hospital360 enrolled1 locationNCT07539883
Recruiting

In Vivo Antibiotics Removal During Hemoadsorption Cartridges and Continuous Renal Replacement Therapy in the Intensive Care Unit

Septic Shock
Niguarda Hospital20 enrolled1 locationNCT07230041
Recruiting
Phase 2

Study SOLACE SEPSIS

Septic ShockIntracranial Hypertension
University Hospital Pilsen40 enrolled1 locationNCT06634069
Recruiting
Not Applicable

Peripheral Perfusion Index-guided Fluid Resuscitation for Preventing Acute Skin Failure in Elderly Critically Ill Patients

SepsisSeptic ShockAcute Skin Failure
Ying Wang216 enrolled1 locationNCT07367113
Recruiting

The PvCO2-PaCO2/CaO2-CvO2 Ratio in Septic Shock

Septic Shock
Avicenna Military Hospital30 enrolled3 locationsNCT07096284
Recruiting
Not Applicable

Neuromodulation to Regulate Inflammation and Autonomic Imbalance in Sepsis

Septic Shock
University of Oklahoma34 enrolled1 locationNCT03992378