RecruitingNCT06723938

Phenotypic and Genotypic Characterisation of a Large, Multicentre Italian Cohort of 46, XY DSD Patients


Sponsor

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Enrollment

520 participants

Start Date

Jun 15, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

Observational exploratory study of a cohort of pediatric and adolescent patients diagnosed with DSD karyotype 46,XY, a rare congenital clinical condition characterized by a disharmonic development between chromosomal sex, gonadal sex and/or phenotypic sex.


Eligibility

Max Age: 18 Years

Inclusion Criteria5

  • Karyotype 46,XY DSD;
  • Genital ambiguity signs assessed on the basis of clinical phenotype and EMS/EGS for karyotype 46,XY DSD;
  • Age < 18 years at diagnosis of 46,XY DSD;
  • Patients referred to the IRCCS Azienda Ospedaliero-Universitaria di Bologna since 01/01/1991 or to other participating centres since 01/01/2000;
  • Obtaining informed consent from patients or from parents/legal guardian of pediatric patients.

Exclusion Criteria1

  • None.

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Locations(4)

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Bologna, Bologna, Italy

IRCCS Ospedale San Raffaele

Milan, Milano, Italy

Azienda Ospedaliero Universitaria Pisana

Pisa, Pisa, Italy

Ospedale Pediatrico Bambino Gesù

Roma, Roma, Italy

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NCT06723938


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