RecruitingPhase 2NCT06731894

Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

A Pilot Study to Evaluate the Benefits of Phytocannabinoids for the Treatment of Chronic Chemotherapy-Induced Peripheral Neuropathy

Sponsor

City of Hope Medical Center

Enrollment

120 participants

Start Date

Oct 3, 2025

Study Type

INTERVENTIONAL

Conditions

Breast Carcinoma

Summary

This phase II trials evaluates how well different types of phytocannabinoids (cannabidiol \[CBD\] versus tetrahydrocannabinol \[THC\] and CBD formulation \[THC:CBD\]) work to reduce chronic chemotherapy-induced peripheral neuropathy among breast and colon cancer survivors. Chemotherapy induced peripheral neuropathy is a set of symptoms that includes pain, tingling, numbness and motor weakness caused by certain types of chemotherapy treatment. Phytocannabinoids are compounds made by the cannabis plant, such as THC and CBD, that have been found to be an effective treatment for chronic pain. Phytocannabinoids may be effective in reducing chronic chemotherapy-induced peripheral neuropathy symptoms in patients treated for breast or colon cancer.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether medical cannabis (containing phytocannabinoids) can reduce long-lasting nerve pain and tingling in the hands and feet (peripheral neuropathy) that was caused by chemotherapy in breast and colon cancer survivors. **You may be eligible if...** - You are 18 or older and a breast or colon cancer survivor - You have ongoing nerve pain or numbness in your hands or feet (Grade 1 or higher neuropathy) that developed from chemotherapy - You are in reasonably good overall health - You are able to read and understand English - You are willing to use medical cannabis as part of the study **You may NOT be eligible if...** - You are currently receiving chemotherapy or are in active cancer treatment - You have conditions that would make cannabis use unsafe - You are pregnant or planning to become pregnant - You cannot complete the follow-up assessments required Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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