RecruitingPhase 1NCT06733441

A Study of TLN-254 in Participants With Relapsed or Refractory T-cell Lymphoma

Phase 1b, Randomized, Dose Optimization Study to Assess the Anti-Tumor Activity, Safety, and Pharmacokinetics of TLN-254 in Patients With Relapsed or Refractory T-cell Lymphoma


Sponsor

Treeline Biosciences, Inc.

Enrollment

50 participants

Start Date

Dec 16, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The primary purpose of this study is to evaluate the anti-tumor activity of TLN-254 monotherapy in participants with relapsed or refractory T-cell lymphoma.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new drug called TLN-254 in people with T-cell lymphoma — a rare type of blood cancer — that has come back or stopped responding to prior treatment. The study includes multiple types of T-cell lymphoma. **You may be eligible if...** - You are 18 or older - You have been diagnosed with peripheral T-cell lymphoma (PTCL) or cutaneous T-cell lymphoma (CTCL) that has relapsed or is refractory (not responding) after at least one prior treatment - If you have a specific subtype called anaplastic large cell lymphoma (ALCL), you must have previously received brentuximab vedotin - You have measurable disease on imaging - Your organ function is adequate **You may NOT be eligible if...** - You have active brain involvement by lymphoma - You have uncontrolled serious infections or other active cancers - You have had certain prior treatments that would exclude you based on the protocol - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGTLN-254

TLN-254 will be administered orally at a specified dose on specified days depending on treatment allocation.

DRUGTLN-254

TLN-254 will be administered orally at a specified dose on specified days.


Locations(5)

Stanford Cancer Institute

Stanford, California, United States

Washington University School of Medicine

St Louis, Missouri, United States

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Sarah Cannon Research Institute

Nashville, Tennessee, United States

British Columbia Cancer Agency

Vancouver, British Columbia, Canada

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06733441


Related Trials