Odronextamab in Low Tumor Volume Advanced FL

This study is testing a drug called odronextamab — a bispecific antibody that helps the immune system attack lymphoma cells — in people with follicular lymphoma (a slow-growing blood cancer) that has not yet grown large or caused symptoms. **You may be eligible if...** - You are 18 or older - You have been diagnosed with follicular lymphoma grade 1, 2, or 3A confirmed by biopsy - Your cancer is CD20-positive - You had a lymph node biopsy in the past 6 months - You have at least one enlarged lymph node (1.5 cm or larger) - Your organ function (blood counts, heart, etc.) is adequate **You may NOT be eligible if...** - Your lymphoma has transformed to a more aggressive type - You have cancer spread to the brain or spinal fluid - You have active autoimmune disease requiring treatment - You have serious heart, liver, kidney, or lung problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.