RecruitingNCT06735014

Multicenter ALS Imaging Study

Multicenter Longitudinal Imaging in ALS for Disease Biomarker Development


Sponsor

University of Minnesota

Enrollment

90 participants

Start Date

Sep 15, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This is a multi-site study of ALS participants and healthy controls who will undergo brain and cervical spine MRIs and NfL blood testing at up-to 4 time points over the course of a year. The primary goal is to identify objective biomarkers of disease progression that are biologically relevant, linearly progressive, and sensitive to change.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Magnetic Resonance Imaging and Plasma neurofilament light chain (NfL) quantification for people with als and amyotrophic lateral sclerosis. The study is currently recruiting participants at 3 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTMagnetic Resonance Imaging

Participants will undergo 3T MRI scanning of the brain and cervical spine MRIs

DIAGNOSTIC_TESTPlasma neurofilament light chain (NfL) quantification

Participants will undergo a blood draw for the quantification of plasma neurofilament light chain


Locations(3)

University of Florida

Gainesville, Florida, United States

Northwestern University

Evanston, Illinois, United States

University of Minnesota

Minneapolis, Minnesota, United States

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NCT06735014


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