RecruitingPhase 4NCT06739473

Total-body Glucose Utilization in Obesity

Sponsor

Turku University Hospital

Enrollment

60 participants

Start Date

Jan 25, 2023

Study Type

INTERVENTIONAL

Conditions

Obesity and Overweight

Summary

There are three goals for this study. One is to investigate how different emotions and exposure to cold affect blood flow in the body. The second aim is to study how insulin affects blood flow and tissue glucose uptake, and to study whether this effect is altered in obesity. Last, the study focuses on establishing the lowest dose of a PET radiotracer, oxygen-15 labelled water, that can be used in clinical studies with a new whole-body PET scanner.

Eligibility

Min Age: 20 YearsMax Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called CEUS or Contrast enhanced Ultrasound, a behavioral approach called Cold, and others for people with obesity and overweight. The study is currently recruiting participants at 1 location. People eligible for this study include aged 20 Years to 60 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALMovies

Participants will watch eight short movie clips, and the changes different emotions evoked by the clips will be studied using H2\[15O\]O PET/CT.

BEHAVIORALCold

Participants will be studied with H2\[15O\]O PET/CT while one of their legs will be exposed to cold to study the effects of cold stimulus on whole-body blood flow.

DRUGHyperinsulinemic euglycemic clamp

Participants will be administered intravenous fast acting insulin (NovoRapid, Novo Nordisk, 1 mU/m2 body surface area/min) together with 20 % glucose to maintain normal glucose values (5.0 mmol/L) to study the effects of insulin on whole body blood flow with H2\[15O\]O PET/CT, and to assess tissue insulin-stimulated glucose uptake with \[18F\]FDG PET/CT.

RADIATIONH2[15O]O PET/CT

H2\[15O\]O PET/CT, with a dose of 25-700 MB/bolus repeated 2-8 times per scan.

RADIATION[18F]FDG PET/CT

Whole-body \[18F\]FDG PET/CT scan to study tissue glucose uptake, dose 100 MBq

DRUGCEUS or Contrast enhanced Ultrasound

Contrast-enhanced ultrasound of left forearm muscles is performed during fasting and after 30-40 minutes of hyperinsulinemia