Scaling Up Community-based Noncommunicable Disease Research Into Practice in Pokhara Metropolitan City of Nepal
Johns Hopkins Bloomberg School of Public Health
2,070 participants
Apr 28, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to evaluate whether a multifaceted community-based intervention, comprising 1) screening and lifestyle counseling by female community health volunteers (FCHVs); community health workers in Nepal, through home visits, and 2) regular Short Message Service (SMS) messages, can effectively reduce systolic blood pressure (SBP), lower fasting blood glucose, and increase smoking cessation rates among adults living in Pokhara with hypertension, type 2 diabetes, and smoking habits, respectively. The main research questions are: * Can FCHV home visits combined with regular mobile phone messages focused on blood pressure management reduce systolic blood pressure in adults with hypertension? * Can FCHV home visits combined with regular mobile phone messages focused on diabetes management lower fasting blood glucose levels in adults with type 2 diabetes? * Can FCHV home visits combined with regular mobile phone messages focused on smoking cessation increase the cessation rate among current smokers? Researchers will compare the intervention group with a usual care group, which does not receive regular FCHV home visits for managing the three aforementioned risk factors or mobile phone messages.
Eligibility
Inclusion Criteria10
- Meeting at least one of the following three conditions
- Hypertensive, defined as
- BP≥140/90 mmHg at two separate measurements
- Type 2 diabetes, defined as
- Fingerprick glucose≥100 mg/dL, and plasma fasting glucose ≥126 mg/dL, and HbA1c≥6.5
- Current smoker, defined as
- Ever smoked ≥100 cigarettes in lifetime, and
- Currently smokes every day.
- Registered on the voter list in Pokhara.
- Not planning to migrate outside of Pokhara during the study period
Exclusion Criteria15
- Blood pressure ≥180/120 mmHg or
- Blood glucose \>250 mg/dL or \<54 mg/dL
- Diagnosed with secondary hypertension by health professionals
- Diagnosed with other diabetes besides type 2 by health professionals
- Presenting with acute symptoms that may require hospitalizations, which includes but not limited to:
- Nausea, vomiting, diarrhea
- Abdominal pain
- Polyuria, polydipsia, polyphagia
- Loss of motor or sensory function
- Altered mental status.
- Chest pain, chest tightness
- Dyspnea, shortness of breath
- Fever
- Diagnosed as terminally ill by a health professional, defined as life expectancy of 6 months or less.
- Pregnant or intend to be pregnant
Interventions
1. FCHV home visits every three months, including * For hypertension i. Blood pressure measurement with digital BP devices ii. Lifestyle counseling iii. Referral if uncontrolled BP (≥140/90 mmHg) for 3 months * For type 2 diabetes i. Fasting blood glucose measurement with glucometer ii. Lifestyle counseling focusing on diabetes management iii. Referral if uncontrolled diabetes (≥126mg/dl) for 3 months * For current smokers i. Smoking cessation counseling ii. Referral for nicotine replacement therapy if request by participants 2. Mobile phone messages, including * Lifestyle modification * Conveyed as voice or text messages, depending on participant preference
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06740708