NearWave Optical Molecular Monitoring

This study uses a non-invasive light-based device (near-infrared optical imaging) to monitor how breast tumors respond to chemotherapy given before surgery (neoadjuvant chemotherapy). The device measures changes in the tumor using light, without radiation, to see if it can predict treatment response. **You may be eligible if...** - You are a woman aged 18 or older - You have been diagnosed with invasive breast cancer (HER2-positive or triple-negative subtype) - Your tumor is at least 2 cm in size - You are scheduled to receive chemotherapy before surgery (neoadjuvant treatment) - Your tumor is palpable (felt by your doctor) **You may NOT be eligible if...** - You have inflammatory breast cancer - You have had previous breast cancer requiring surgery or radiation in either breast - You are pregnant or nursing - Your BMI is 40 or above (unless the tumor is very close to the skin surface) - You have tattoos on your breasts Talk to your doctor to see if this trial is right for you.