RecruitingNot ApplicableNCT06747091

ARIADNE Clinical Trial

Adjuvant Ablation for PeRsistent AtrIal FibrillAtion Using Dual ENergy LatticE Tip Catheter: ARIADNE-Randomized Clinical Trial

Sponsor

Stavros E Mountantonakis

Enrollment

60 participants

Start Date

Mar 18, 2025

Study Type

INTERVENTIONAL

Conditions

Persistent Atrial Fibrillation

Summary

A prospective multi-arm parallel group randomized clinical trial to compare the efficacy of three ablation strategies in patients with persistent atrial fibrillation using using a lattice-tip catheter that can switch between RFA and PFA energy. The incremental benefit of posterior wall isolation (PWI) and mitral isthmus ablation may contribute to greater freedom from atrial fibrillation at twelve months.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

The ARIADNE trial is studying a type of heart procedure called catheter ablation to treat persistent atrial fibrillation (AFib) — an irregular heart rhythm that has lasted more than 7 days but less than 12 months. The goal is to find the best way to restore a normal heart rhythm. **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with persistent AFib confirmed by a doctor and an ECG (heart tracing) - Your AFib has lasted more than 7 days but less than 12 months - You are considered a suitable candidate for catheter ablation - You are willing and able to attend all follow-up visits throughout the study **You may NOT be eligible if...** - Your AFib is caused by something reversible, like a thyroid problem, electrolyte imbalance, or alcohol use - You have had a previous heart ablation or cardiac surgery involving the left side of the heart - You have had a valve repair or replacement procedure Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURECatheter Ablation

This is a prospective randomized clinical trial. Patients will undergo catheter ablation for persistent AF using a lattice-tip catheter that can switch between RFA and PFA energy. Enrolled patients will be randomized to one of three ablation strategies: