Persistent Atrial Fibrillation Clinical Trials

33 recruiting

Persistent Atrial Fibrillation Trials at a Glance

37 actively recruiting trials for persistent atrial fibrillation are listed on ClinicalTrialsFinder across 6 cities in 23 countries. The largest study group is Not Applicable with 28 trials, with the heaviest enrollment activity in New York, Naples, and Jonesboro. Lead sponsors running persistent atrial fibrillation studies include Boston Scientific Corporation, Vivek Reddy, and Abbott Medical Devices.

Browse persistent atrial fibrillation trials by phase

Treatments under study

About Persistent Atrial Fibrillation Clinical Trials

Looking for clinical trials for Persistent Atrial Fibrillation? There are currently 33 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Persistent Atrial Fibrillation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Persistent Atrial Fibrillation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 37 trials

Recruiting
Not Applicable

PVI Alone vs PVI and Linear Ablation for Persistent Atrial Fibrillation (PROMPT AF II)

Persistent Atrial Fibrillation
Boston Scientific Corporation640 enrolled1 locationNCT07106970
Recruiting
Not Applicable

Feasibility Study of the FARAFLEX Mapping and PFA System

Atrial FibrillationPersistent Atrial FibrillationParoxysmal AF
Boston Scientific Corporation250 enrolled4 locationsNCT06510556
Recruiting

REPRESENT-PF Registry

Persistent Atrial FibrillationParoxysmal Atrial Fibrillation
Vivek Reddy275 enrolled2 locationsNCT07535268
Recruiting
Not Applicable

Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)

Atrial Fibrillation (AF)Persistent Atrial FibrillationParoxysmal Atrial Fibrillation (PAF)
Medtronic Cardiac Ablation Solutions400 enrolled30 locationsNCT07298473
Recruiting
Not Applicable

BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF

Atrial FibrillationAtrial ArrhythmiaPersistent Atrial Fibrillation+1 more
Abbott Medical Devices300 enrolled22 locationsNCT07181590
Recruiting

SPHERE Per-AF Post-Approval Study

Persistent Atrial Fibrillation
Medtronic Cardiac Ablation Solutions200 enrolled14 locationsNCT06858306
Recruiting
Phase 4

Study on the Prevention of Atrial Fibrillation Recurrence After Ablation by Qidong Yixin Granule

Persistent Atrial Fibrillation
Sir Run Run Shaw Hospital846 enrolled5 locationsNCT07508618
Recruiting
Not Applicable

Evaluation of Novel Waveforms Delivered Using the FARAPULSE™ PFA System

Persistent Atrial FibrillationParoxysmal Atrial Fibrillation
Boston Scientific Corporation200 enrolled2 locationsNCT07444320
Recruiting
Not Applicable

Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System

Persistent Atrial Fibrillation
Boston Scientific Corporation376 enrolled34 locationsNCT06735534
Recruiting
Not Applicable

Endocardial Mapping With the CoreMap EP Mapping System

Persistent Atrial Fibrillation
CoreMap Inc.245 enrolled3 locationsNCT06529978
Recruiting
Not Applicable

Medtronic Terminate AF Study

Persistent Atrial FibrillationLongstanding Persistent Atrial Fibrillation
Medtronic Cardiac Surgery160 enrolled15 locationsNCT03546374
Recruiting
Not Applicable

A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter

CardiomyopathyVentricular TachycardiaPersistent Atrial Fibrillation+7 more
Biosense Webster, Inc.60 enrolled6 locationsNCT07116525
Recruiting
Not Applicable

EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment

Mild Cognitive ImpairmentPersistent Atrial Fibrillation
Poitiers University Hospital120 enrolled8 locationsNCT05790707
Recruiting
Not Applicable

FIH Study of PFLotus in Persistent Atrial Fibrillation

Persistent Atrial Fibrillation
The Third People's Hospital of Chengdu40 enrolled1 locationNCT07301190
Recruiting
Phase 4

Evaluation of Two Different Regimens of the Antiarrhythmic Drug Amiodarone to Maintain Normal Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation

Persistent Atrial Fibrillation
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau312 enrolled1 locationNCT07273994
Recruiting
Not Applicable

ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients

Persistent Atrial FibrillationParoxysmal Atrial Fibrillation
Vivek Reddy250 enrolled8 locationsNCT05988411
Recruiting
Phase 4

Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related Arrhythmias

Persistent Atrial FibrillationParoxysmal Atrial FibrillationLong-standing Persistent Atrial Fibrillation
Vivek Reddy275 enrolled5 locationsNCT06765356
Recruiting
Not Applicable

Hybrid Ablation of Atrial Fibrillation in Heart Failure

Heart FailureAtrial FibrillationAtrial Arrhythmia+3 more
St. George's Hospital, London120 enrolled7 locationsNCT05411614
Recruiting
Not Applicable

Acute Responses to Exercise in Females and Males With Symptomatic Atrial Fibrillation

Atrial FibrillationPersistent Atrial FibrillationParoxysmal Atrial Fibrillation
Ottawa Heart Institute Research Corporation36 enrolled1 locationNCT05085860
Recruiting
Not Applicable

VOLT CE Mark Study

Atrial FibrillationAtrial ArrhythmiaPersistent Atrial Fibrillation+1 more
Abbott Medical Devices300 enrolled16 locationsNCT06106594