Persistent Atrial Fibrillation Clinical Trials

29 recruiting

Frequently Asked Questions

Common questions about Persistent Atrial Fibrillation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 32 trials

Recruiting
Not Applicable

Endocardial Mapping With the CoreMap EP Mapping System

Persistent Atrial Fibrillation
CoreMap Inc.245 enrolled3 locationsNCT06529978
Recruiting
Not Applicable

Medtronic Terminate AF Study

Persistent Atrial FibrillationLongstanding Persistent Atrial Fibrillation
Medtronic Cardiac Surgery160 enrolled15 locationsNCT03546374
Recruiting
Not Applicable

BaLloon-based PFA Ablation poST Approval Outcomes for PAF and PersAF

Atrial FibrillationAtrial ArrhythmiaPersistent Atrial Fibrillation+1 more
Abbott Medical Devices300 enrolled22 locationsNCT07181590
Recruiting
Not Applicable

Feasibility Study of the FARAFLEX Mapping and PFA System

Atrial FibrillationPersistent Atrial FibrillationParoxysmal AF
Boston Scientific Corporation250 enrolled4 locationsNCT06510556
Recruiting
Not Applicable

Evaluation of Novel Waveforms Delivered Using the FARAPULSE™ PFA System

Persistent Atrial FibrillationParoxysmal Atrial Fibrillation
Boston Scientific Corporation200 enrolled1 locationNCT07444320
Recruiting
Not Applicable

Repeat Ablation of Persistent Atrial Fibrillation, Including Mitral Isthmus Catheter Ablation, With the FARAPULSE Pulsed Field Ablation System

Persistent Atrial Fibrillation
Boston Scientific Corporation407 enrolled32 locationsNCT06735534
Recruiting
Not Applicable

A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter

CardiomyopathyVentricular TachycardiaPersistent Atrial Fibrillation+7 more
Biosense Webster, Inc.60 enrolled6 locationsNCT07116525
Recruiting

SPHERE Per-AF Post-Approval Study

Persistent Atrial Fibrillation
Medtronic Cardiac Ablation Solutions200 enrolled12 locationsNCT06858306
Recruiting
Not Applicable

PVI Alone vs PVI and Linear Ablation for Persistent Atrial Fibrillation (PROMPT AF II)

Persistent Atrial Fibrillation
Boston Scientific Corporation640 enrolled1 locationNCT07106970
Recruiting
Not Applicable

EfFect of Ablation of Persistent AtriaL Fibrillation on COgNitive Function in Individuals With Mild Cognitive Impairment

Mild Cognitive ImpairmentPersistent Atrial Fibrillation
Poitiers University Hospital120 enrolled8 locationsNCT05790707
Recruiting
Not Applicable

FIH Study of PFLotus in Persistent Atrial Fibrillation

Persistent Atrial Fibrillation
The Third People's Hospital of Chengdu40 enrolled1 locationNCT07301190
Recruiting
Phase 4

Evaluation of Two Different Regimens of the Antiarrhythmic Drug Amiodarone to Maintain Normal Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation

Persistent Atrial Fibrillation
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau312 enrolled1 locationNCT07273994
Recruiting
Not Applicable

ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients

Persistent Atrial FibrillationParoxysmal Atrial Fibrillation
Vivek Reddy250 enrolled8 locationsNCT05988411
Recruiting
Phase 4

Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related Arrhythmias

Persistent Atrial FibrillationParoxysmal Atrial FibrillationLong-standing Persistent Atrial Fibrillation
Vivek Reddy275 enrolled5 locationsNCT06765356
Recruiting
Not Applicable

Hybrid Ablation of Atrial Fibrillation in Heart Failure

Heart FailureAtrial FibrillationAtrial Arrhythmia+3 more
St. George's Hospital, London120 enrolled7 locationsNCT05411614
Recruiting
Not Applicable

Acute Responses to Exercise in Females and Males With Symptomatic Atrial Fibrillation

Atrial FibrillationPersistent Atrial FibrillationParoxysmal Atrial Fibrillation
Ottawa Heart Institute Research Corporation36 enrolled1 locationNCT05085860
Recruiting
Not Applicable

VOLT CE Mark Study

Atrial FibrillationAtrial ArrhythmiaPersistent Atrial Fibrillation+1 more
Abbott Medical Devices300 enrolled16 locationsNCT06106594
Recruiting
Not Applicable

ARIADNE Clinical Trial

Persistent Atrial Fibrillation
Stavros E Mountantonakis60 enrolled3 locationsNCT06747091
Recruiting
Not Applicable

Investigation of Cardioversion Versus Therapeutic Ablation for Persistent AF (ORBICA-AF)

Catheter AblationPersistent Atrial FibrillationCardiac Arrhythmia
Barts & The London NHS Trust208 enrolled1 locationNCT06096246
Recruiting
Not Applicable

Pulsed Field Ablation vs. Cryoballoon Ablation in Patients With Persistent Atrial Fibrillation

Persistent Atrial Fibrillation
Kitasato University300 enrolled1 locationNCT07064616