RecruitingNot ApplicableNCT06747871

Opioids, Low Nicotine Cigarettes, and Chronic Pain

Targeting Reinforcement Mechanisms for Smoking Cessation Using Very Low Nicotine Content Cigarettes in Individuals With Opioid Use Disorder and Chronic Pain

Sponsor

Duke University

Enrollment

60 participants

Start Date

Apr 15, 2025

Study Type

INTERVENTIONAL

Conditions

Chronic Pain Tobacco Use Opioid Substitution Treatment

Summary

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).

Eligibility

Min Age: 21 Years

Inclusion Criteria7

Aged 21+ years who smoke cigarettes daily
Chronic non-cancer musculoskeletal pain secondary to structural changes (e.g., low back pain, osteoarthritis)
Have received stable office-based buprenorphine treatment for opioid use disorder for at least 30 days
Self-report smoking at least 10 cigarettes/day
Expired breath carbon monoxide (CO) level >8 ppm
Have a smartphone capable of running software for ecological momentary assessment
Open to exploring the possibility of quitting smoking

Exclusion Criteria11

Pain specifically due to cancer
Other significant health problems
Major surgery within the past 6 months or planned surgery within the timeframe of the study
Current disability litigation
Use of electronic cigarettes or other non-cigarette tobacco products > 9 of the past 30 days
Current use of nicotine replacement therapy or other cessation treatment
Current daily or near-daily cannabis use
History of psychotic disorder
Acute suicidality or current unstable psychiatric disorder
Positive pregnancy test
Actively seeking smoking cessation treatment