RecruitingNot ApplicableNCT06747871

Opioids, Low Nicotine Cigarettes, and Chronic Pain

Targeting Reinforcement Mechanisms for Smoking Cessation Using Very Low Nicotine Content Cigarettes in Individuals With Opioid Use Disorder and Chronic Pain


Sponsor

Duke University

Enrollment

60 participants

Start Date

Apr 15, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on craving, withdrawal, and pain among individuals with chronic pain who smoke cigarettes daily and are attending office-based buprenorphine treatment (OBBT).


Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Normal Nicotine Cigarettes (NNC) and a behavioral approach called Very Low Nicotine Cigarettes (VLNC) for people with chronic pain, opioid substitution treatment, and other related conditions. The study is currently recruiting participants at 1 location. People eligible for this study include aged 21 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALVery Low Nicotine Cigarettes (VLNC)

Spectrum NRC 102/103 (nonmenthol/ menthol) cigarettes, which have a nicotine content of approximately 0.4 mg/g tobacco.

BEHAVIORALNormal Nicotine Cigarettes (NNC)

Spectrum NRC 600/601 (nonmenthol/ menthol) cigarettes, which have a nicotine content of approximately 15.8 mg/g tobacco.


Locations(1)

North Pavilion

Durham, North Carolina, United States

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NCT06747871


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