RecruitingNot ApplicableNCT06747910

Assessment of Remote Approaches for Identification of Autonomic Dysfunction Among Survivors of Leukemia and Lymphoma


Sponsor

St. Jude Children's Research Hospital

Enrollment

188 participants

Start Date

Feb 3, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This study seeks to determine if diagnosing cardiac autonomic dysfunction (AD) can be done remotely with the same accuracy as in-person testing. If so, the identification of AD could happen sooner, facilitating remote studies of the condition and potentially reducing the risk of illness. Childhood cancer survivors, particularly survivors of acute lymphoblastic leukemia (ALL) and Hodgkins's lymphoma (HL), appear to be at increased risk for AD. Primary Objectives: * To determine the sensitivity and specificity of heart rate variability (HRV), measured remotely with biosensor technology (Actigraph LEAP), compared to in-person assessment using the Ewing battery as the reference standard to identify cardiac autonomic dysfunction (AD) among survivors of leukemia and lymphoma. * To determine the sensitivity and specificity of the Composite Autonomic Symptom Scale 31 (COMPASS31) compared to the Ewing battery to identify AD among leukemia and lymphoma survivors.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating heart health problems in survivors of childhood leukemia and lymphoma. Specifically, researchers are looking at whether remote (at-home) tests can identify autonomic dysfunction — a condition where the part of the nervous system that controls heart rate and blood pressure is not working properly, which can be a long-term side effect of cancer treatment. **You may be eligible if...** - You are over 18 years old - You are a participant in the St. Jude Lifetime Cohort (SJLIFE) study - You were originally diagnosed with acute lymphoblastic leukemia (ALL), Hodgkin's lymphoma, or Non-Hodgkin's lymphoma - You are not currently taking beta-blocker medications **You may NOT be eligible if...** - You cannot speak, read, or understand English - You are unable to follow the test instructions - You have active heart failure with worsening symptoms - You are currently pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERExercise Intervention - Ewing Battery Assessment

Undergo in-person Ewing battery assessment

OTHERQuestionnaire Administration

Receive COMPASS31 questionnaire

DEVICEMedical Device Usage and Evaluation

Wear biosensensor heart monitor that remotely collects heart rate variability.


Locations(1)

St. Jude Children's Research Hospital

Memphis, Tennessee, United States

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NCT06747910


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