RecruitingPhase 2NCT06755684

Neoadjuvant Befotertinib Combined Bevacizumab or Platinum-based Double Chemotherapy for Resectable Locally-advanced EGFR Mutation-positive Non-Small Cell Lung Cancer

Neoadjuvant Befotertinib Combined Bevacizumab or Platinum-based Double Chemotherapy for Resectable Locally-advanced EGFR Mutation-positive Non-Small Cell Lung Cancer: a Single-center, Randomized Controlled Trial


Sponsor

Peng Zhang

Enrollment

60 participants

Start Date

Nov 7, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study targeted patients with resectable stage II-IIIA non-small cell lung cancer with EGFR mutation


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether using befotertinib (a targeted EGFR-blocking drug) combined with bevacizumab or standard platinum-based chemotherapy before surgery can shrink tumors and improve surgical outcomes in people with early-to-mid stage non-small cell lung cancer (NSCLC) that has an EGFR mutation. **You may be eligible if...** - You are 18–75 years old with NSCLC confirmed to have an EGFR-sensitive mutation - Your cancer is at stage II–IIIA and has not spread to distant organs - You are eligible for and can tolerate curative surgery - You have not received any prior cancer treatment for NSCLC - You have good lung and organ function **You may NOT be eligible if...** - You have already received any systemic cancer treatment for your lung cancer - You have unstable medical conditions such as uncontrolled high blood pressure, active infection, or severe angina - Your cancer has spread to the brain or other distant sites Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBefotertinib combined Bevacizumab

Befotertinib combined Bevacizumab

DRUGBefotertinib combined platinum-based double chemotherapy

Befotertinib combined platinum-based double chemotherapy


Locations(1)

Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

View Full Details on ClinicalTrials.gov

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NCT06755684


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