RecruitingNot ApplicableNCT06758817

The Triad of Nutrition, Intestinal Microbiota and Rheumatoid Arthritis (TASTY)


Sponsor

Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa

Enrollment

100 participants

Start Date

Jan 2, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The main goal of this trial is to investigate whether a dietary intervention based on a typical Mediterranean Diet enriched with fermented foods (MedDiet+) can impact gut microbiota and RA-related outcomes.


Eligibility

Min Age: 18 Years

Inclusion Criteria7

  • RA patients (ACR/EULAR2010 criteria)
  • Age \>18-years
  • Disease duration \>1-year
  • Active disease (DAS28 \> 2.6units)
  • On stable medication for 12 weeks
  • Low/medium MedDiet adherence (PREDIMED\<10)
  • Willing to comply with study protocol

Exclusion Criteria12

  • Prednisolone dose ≥ 7.5 mg/day
  • Antibiotic therapy 4-weeks prior to baseline
  • Persistent use of NSAID's
  • Inflammatory or irritable bowel disease
  • Celiac disease
  • Chronic diarrhea
  • Diabetes
  • Other immune-mediated inflammatory diseases besides RA
  • Major organ dysfunction
  • Cancer diagnosed in the last five years
  • Health conditions which may difficult participation (cognitive impairment/psychiatric disease)
  • Pregnant or lactating individuals

Interventions

OTHERMedDiet+ intervention

Study arm will consume a Mediterranean like style diet enriched in fermented foods for 12 weeks

OTHERGeneral dietary recommendations

Study arm will be given general healthy eating advice at baseline.


Locations(2)

Unidade Local de Saude de Santa Maria

Lisbon, Portugal, Portugal

Faculdade Medicina de Lisboa

Lisbon, Portugal, Portugal

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NCT06758817