Dietary Impact on Sleep, Rhythms and Related Physiology
Inverkan av Kost pa Dygnsrytmer Och Amnesomsattning
Uppsala University
24 participants
Sep 22, 2025
INTERVENTIONAL
Conditions
Summary
Sleep and metabolism are closely interconnected, and emerging evidence suggests that dietary composition may influence both sleep quality and key physiological functions such as glucose regulation, cardiovascular activity, and hormonal signaling. This study aims to investigate how a Western-style unhealthy diet versus a healthier, fiber-rich diet affects objective and subjective sleep measures, 24-hour physiological parameters, and a range of biomarkers related to cardiometabolic, neurodegenerative, and gut microbial function.
Eligibility
Inclusion Criteria7
- Age 18-32 yr
- Healthy (self-reported) and not on chronic medication
- BMI 18-27 kg/m2 (and waist circumference <102 cm), and weight stable (less than 5% body weight change in the past 6 months)
- Non-smoker and non-nicotine user
- Regular sleep-wake pattern, with sleep duration of 7-9.25 hrs per night
- Regular exercise habits the last 2 months
- Regular daily meal pattern with 3 main meals
Exclusion Criteria14
- Major or chronic illness, e.g. diabetes, renal disease or inflammatory bowel disease
- Current or history of endocrine or metabolic disorders
- Psychiatric or neurological disorders (e.g. bipolar disorder, epilepsy)
- Frequent gastrointestinal symptoms
- Chronic medication
- Any sleep disorder (including recent or chronic symptoms of insomnia)
- Shift work in the preceding three months or for a long duration
- Extreme chronotype or physical activity patterns
- Time travel over two time zones in the preceding month
- Too much weight gain or weight loss in the preceding 6 months (±5% body weight in past 6 months)
- Any issues with or allergies against the provided food items
- Recent major dietary changes or adoption of specific dietary regimens
- Women who are pregnant, breastfeeding, or planning to become pregnant during the study period.
- Use of illicit drugs or substances of abuse
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Interventions
Low-fat diet for approximately 1 week, preceding in-lab study period (approximately 2 days) under standardized conditions (total dietary exposure up to 9-10 days).
High-fat diet for approximately 1 week, preceding in-lab study period (approximately 2 days) under standardized conditions (total dietary exposure up to 9-10 days).
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07138313