RecruitingNot ApplicableNCT06758856

Effect of Betaine and Choline on Metabolic Health

ABC (Additional Betaine and Choline) Study: Effect of Betaine and Choline Intake on Biomarkers of Metabolic Health in Humans

Sponsor

University of Guelph

Enrollment

34 participants

Start Date

Jan 31, 2025

Study Type

INTERVENTIONAL

Conditions

The purpose of this research is to determine whether extra betaine and choline influence metabolic health in adults with overweight and obesity.

Min Age: 18 YearsMax Age: 70 Years

Male or female participant of any race or ethnicity between 18-70 years of age (inclusive) at the time of informed consent
BMI between 25-35 kg/m2
Non-smoker
Willing to consume 3 eggs per day for one dietary period of 4 weeks
Willing to avoid eggs during the rest of the study including washout period breaks except for eggs that are provided
Willing to fast before the baseline and dietary period lab visits
Willing to provide a 24-hr prior day food record at the dietary period lab visits
Willing to provide or collect biological specimen samples at the baseline and dietary period lab visits
Willing to follow the study protocol including maintaining usual lifestyle during the entire study

Male or female < 18 years or > 70 years of age at the time of consent
BMI < 25 kg/m2; or BMI > 35 kg/m2
Pregnant or planning to become pregnant during the course of the study; currently breastfeeding or postpartum < 6 months
Use of hormone therapy including birth control pills
Follows a vegan diet
Current smoker (any form of nicotine, e-cigarettes, etc)
Use of recreational drugs (may affect metabolic pathway for choline)
Presence of chronic illnesses, e.g., heart disease, diabetes, cancer, celiac disease, inflammatory bowel disease (Crohn's disease and ulcerative colitis), gastrointestinal liver or kidney diseases or alcoholism
Diagnosis of trimethylaminuria (genetic disorder affecting choline use in body)
Use of antibiotics in the last 2 months
Use of prebiotics, probiotics or dietary fiber (i.e., Metamucil) supplements in the last 2 months
Have allergies to eggs or any anaphylactic food allergies
Have a schedule or lifestyle patterns incompatible with the study protocol