RecruitingPhase 3NCT06764797

Investigating the Efficacy of Combining Virtual Reality-Based Mirror Therapy (VRMT) and Transcranial Direct Current Stimulation (tDCS) to Improve Upper Limb Recovery in Patients with Stroke

Investigating the Efficacy of Combining Virtual Reality-Based Mirror Therapy and Transcranial Direct Current Stimulation to Improve Upper Limb Recovery in Patients with Stroke

Sponsor

King Saud University

Enrollment

300 participants

Start Date

Sep 19, 2023

Study Type

INTERVENTIONAL

Conditions

Stroke Stroke Rehabilitaion

Summary

This study will investigate whether combining virtual reality-based mirror therapy (VRMT) and transcranial direct current stimulation (tDCS) alongside conventional physical therapy (CPT) will significantly improve hand function for patients with stroke compared to using VRMT or tDCS alone.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

At least 18 years old.
Stroke patients with unilateral cerebral infarction or hemorrhage, more than three months following the stroke.
Adequate cognitive ability to follow instructions (The Arabic version of the Mini-Mental State Examination scores \> 24).
Modified Ashworth scale score \< 3.
Fugl-Meyer Assessment (FMA) score of 10-58 indicating moderate-to-severe arm impairment.

Exclusion Criteria4

visual impairment and field defect or hemi-sensory inattention and unilateral neglect.
Wernicke's aphasia, or global aphasia, leads to difficulty following instructions.
Any contraindication to NIBS.
Other neurological conditions or participation in another study.

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Interventions

DEVICETranscranial Direct Current Stimulation

tDCS will be used during the sessions. The anodal tDCS (2 mA) will be applied for 20 minutes. Continuous, direct currents. The anodal electrode will be positioned over the ipsilesional primary motor cortex (M1) (C3 or C4, international 10-20 system) of the affected hemisphere and the cathodal electrode over the contralateral orbit.

DEVICEVirtual reality

The VRMT group will receive VRMT game-based training using their non-affected upper limb. using a semi-immersive motion-tracking device.

DEVICETranscranial Direct Current Stimulation compined with virtual reality based mirror therapy

20 minutes of tDCS during 45 minutes of VRMT games.

OTHERConventional physical therapy

45 minutes of conventional physical therapy with sham tDCS