RecruitingNCT06765252

Effect of Genetic Polymorphism on Capecitabine-Induced Toxicity in Egyptian Cancer Patients


Sponsor

Ain Shams University

Enrollment

80 participants

Start Date

Apr 1, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this observational study is to study the effect of a single nucleotide polymorphism in the CES1 gene (rs2244613) on capecitabine-induced toxicity in Egyptian cancer patients. This study will help in understanding the interindividual variability in the CES1 gene and the effect of a single nucleotide polymorphism in this gene (rs2244613) on capecitabine-induced toxicity in participants already taking capecitabine-based chemotherapy as part of their regular medical care.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how genetic differences between patients affect their risk of side effects from capecitabine, a common oral chemotherapy drug, in Egyptian cancer patients. The goal is to help doctors personalize chemotherapy dosing in the future. **You may be eligible if...** - You have been diagnosed with breast cancer or colorectal cancer - You are currently receiving capecitabine-based chemotherapy - You are over 18 years of age - Your general health level allows participation (ECOG score 0-2) **You may NOT be eligible if...** - You are also being treated with irinotecan (another chemotherapy) - You have problems with your upper digestive system that affect how you absorb pills - You have a condition causing chronic diarrhea, such as ulcerative colitis or Crohn's disease - You have malabsorption syndrome or cannot take oral medication Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCapecitabine-based chemotherapy

Participants receiving capecitabine in an oral dose of 1,000-1,250 mg/m2 twice daily for the first 14 days of each 21-day cycle.


Locations(1)

Department of Clinical Oncology, Faculty of Medicine, Menoufia University

Shibīn al Kawm, Menoufia, Egypt

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NCT06765252


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