Stereotactic Radiosurgery Versus Radiofrequency Ablation for Primary Liver Cancer

This trial is comparing two treatments for inoperable liver cancer (hepatocellular carcinoma): stereotactic radiosurgery (a very precise form of radiation therapy) versus radiofrequency ablation (a procedure that uses heat to destroy tumors). The goal is to find out which approach works better for tumors near critical structures. **You may be eligible if...** - You have been diagnosed with hepatocellular carcinoma (primary liver cancer) confirmed by imaging or biopsy - Your tumor is located near a major blood vessel, the diaphragm, the liver capsule, or the liver's blood supply entrance - Your cancer cannot be surgically removed, or it has come back within 2 years after a prior curative treatment - You have 3 or fewer lesions, each no larger than 5 cm - Your liver function is reasonably preserved (Child-Pugh score ≤7, KPS ≥70) **You may NOT be eligible if...** - Your cancer has spread outside the liver - You have already received prior treatment for this liver cancer - Your liver function is significantly impaired - Your general health is too poor to safely undergo either procedure Talk to your doctor to see if this trial is right for you.