RecruitingNCT06768528

Association Between GalectiN-3 and POSt-operative AtrIal Fibrillation After Coronary Artery BypaSs Graft

Association Between Galectin-3 and Post-operative AtrIal Fibrillation After Coronary Artery Bypass Graft

Sponsor

University of Sao Paulo General Hospital

Enrollment

90 participants

Start Date

Jan 1, 2023

Study Type

OBSERVATIONAL

Conditions

Cardiovascular Diseases Post-operative Atrial Fibrillation Post-pericardiotomy Syndrome

Summary

The goal of this observational study is to test the association between high levels of Galectin-3 and the occurrence of post-operative atrial fibrillation after isolated coronary artery bypass grafting (CABG). The main question\[s\] it aims to answer are: * Is Galectin-3 an accurate biomarker to predict higher risk of developing post-operative atrial fibrillation? * Are high levels of Galectin-3 associated to other post-operative complications and major adverse cardiovascular events? Participants will be enrolled during pre-operative evaluation and a peripheral blood sample collection will be performed in the 24h before CABG. Participants will then be followed for a period of 12 months (daily during hospitalization and 3 appointments after hospital discharge) to determine whether patients with higher levels of Galectin-3 will have worse outcomes.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether blood levels of a protein called galectin-3 — which is linked to inflammation and heart scarring — can predict the development of atrial fibrillation (irregular heart rhythm) after coronary artery bypass graft (CABG) surgery. This is an observational study; no experimental treatment is given. **You may be eligible if...** - You are scheduled to undergo coronary artery bypass graft (CABG) surgery - You are able to sign informed consent **You may NOT be eligible if...** - Your kidney function is significantly impaired (eGFR below 30 mL/min) or you are on dialysis - Your heart's pumping function is moderately to severely reduced (ejection fraction below 40%) - You have a history of atrial fibrillation before surgery - You are pregnant - You are having valve surgery at the same time as your bypass Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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