RecruitingPhase 2NCT06771518

Association of Thoraco-mediastinal Radiotherapy With Maintenance Immunotherapy Treatment With Atezolizumab

Lung Microcytoma Extensive Disease: Prospective Study of Association of Thoraco-mediastinal Radiotherapy With Maintenance Immunotherapy Treatment With Atezolizumab


Sponsor

Regina Elena Cancer Institute

Enrollment

37 participants

Start Date

Dec 15, 2021

Study Type

INTERVENTIONAL

Conditions

Summary

Investigate the role of consolidative radiotherapy treatment at the thoraco-mediastinal level in the patient suffering from lung microcytoma - extensive disease and treated with chemo-immunotherapy with atezolizumab, in association with maintenance therapy with atezolizumab.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding chest/mediastinal radiation therapy after chemotherapy combined with immunotherapy (atezolizumab) extends survival and prevents cancer recurrence in people with extensive-stage small cell lung cancer (a fast-growing lung cancer that has already spread) who responded to their initial treatment. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of small cell lung cancer (extensive/widespread disease) - You achieved at least a partial response after first-line chemo-immunotherapy - Your general health is adequate (ECOG 0-2) - You have had appropriate staging scans (CT, PET, brain MRI) **You may NOT be eligible if...** - You have previously received radiotherapy to the chest or mediastinum - Your cancer progressed during or after chemo-immunotherapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONThoracic radiotherapy

Thoracic radiotherapy using 4D technique by irradiating the initial sites of disease (primary tumor and involved hilo-mediastinal lymph nodes). The treatments must be provided with the modulated intensity technique (IMRT or VMAT), treatments with conformal technique (3DCRT) are not permitted, where necessary, the Simultaneous Integrated Boost (SIB) technique can be used.

DRUGAtezolizumab 1200 mg e.v. q21

Radiotherapy treatment associated with Atezolizumab 1200 mg i.v. q21 administered according to clinical practice


Locations(1)

"Regina Elena" National Cancer Institute

Rome, Italy

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NCT06771518


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